Vol. 6 No. 6 (2016): VESTNIK of KSMA

The research study represents the results ofpsycho-physiological characteristics offatigue in medical students o f the first and third year o f study in high school. The problem o f multi-factorial impact on development o f student’s fatigue in education pro­cess has been considered. The modern methods have been used in definition offatigue factors, adaptedfo r international students.

The paper presents the results of the analysis of incidence according to a periodic medical examination by doctors of General practice (family medicine) in comparison with doctors, therapists, centres and polyclinics of Almaty. The first places in the structure of chronic illness have a disease of the circulatory system, the digestive system and diseases of the musculoskeletal and connective tissue. On the basis of mathematical simulation models have been developed based on the incidence of the leading and most popular classes and noso­ logical forms identified chronic diseases the age and experience of the surveyed entities. Installed a curved (parabolic) dependence of the probability offrequency of a chronic pathology among the examined doctors from indicators of age and experience, characterized by the presence of a complex of adverse factors in the labour market. The obtained results allow to speak about the role of working conditions in the occurrence of work-related chronic somatic diseases.

The bioethical aspects of enforcement of surrogacy in the Kyrgyz Republic are considered in the article, an analysis of variety of popular opinions concerning the use of this form of reproductive technologies, as well as possible overcoming ways of problems in practice of surrogacy.

In drinking water the town o f Esil in 92% o f samples the concentration o f chlorides was the MPC, the city average, this figure was 1.03 MAC. The rate o f odor was higher sanitary standards in 58 % o f samples on average 1.3 times. The hardness o f the water in all sampling points were above the sanitary norms and 1.9 MPC.

The article presents the structure ofprimary disability o f adult population by class o f diseases ICD. The retrospective was 10 years (2005-2014). Revealed the presence o f leading causes ofprimary disability conditional environmental diseases (diseases of  the respiratory system and malignant neoplasms).

The thymus gland the central organs of immune system responsible for formation and maintenance biological protection o f an organism апatomic structure тимуса is studied 17 corpses at newborns and old age.people o f different age. Research techniques: 1) Anatomic methods (dis­ sections , measurement). 2) Histologic methods (coloring gemotoksilin-eoziny, on Van-Gizon. A s a result o f scientific research - thymus at newborns consists o fsegments. Under a capsule pass longitudinal connective fibers, mainly collagen type. Different "age” o f little bodies HassalVs is apprecia­ble. On a medulla layer the set o fsmall blood capillaries and lymphatic cracks, and also meet lymphocytes. Together degradation thymus consider­ ably decreases and almost T development - lymphocytes completely stops. In the old ages thymus degradations , reduction and stops the production of T- lymphocytes. In old ages thymus tissues is completely replaced by fa t tissues. The organ has lobes and different sizes. Between lobes present connective tissue and elastic fibers. Number HassalVs corpuscles normally. Lymphoblast’s sometimes forming large clumps. In old ages between the slices partitions erased. Reduction in the number o f lymphocytes and absent o felastic fibers.

Introduction: due to the muscle layer in the wall of the lymph vessels and lymph nodes possess a capsule contractile ability by participating in the promotion of lymph.
Objective: the study o f architectonic capsule bronchopulmonary lymph nodes, the number and relationship o f myocytes with collagen and elastic fibers in adolescence o fpostnatal ontogenesis.
Research methods: produced total preparations by the methodproposed Borisov A.V. Sections were stained with Van Gisone by Weigert.
Results: established indicators o f the number o fmuscle cells located in different parts o fthe capsule bronchopulmonary lymph nodes and their corre­ lation with collagen and elastic fibers.
Conclusions: It is shown that the tendency to the predominance o f the number o f myocytes in the left bronchopulmonary lymph nodes in adolescent
children.

The principal novelty of the work is research related to the practical application of newly developed methods of incubation of dermal auto-fibroblasts (DAFB) using platelet-rich plasma and the medicine of licorice root "Glycyram" (received patent No. 1740 KG).
A comparative analysis of the impact of incubate DAFB grown in the presence of platelet-rich plasma and the medicine of licorice root "Glycyram" on regeneration processes in comparison with the traditional method of burn wounds treatment with the ointment "Levomekol" is carried out. The object of research is laboratory outbred rats weighing 150–200 g. Thermal defeat IIIA degree is applied by contact.
Experimentally it is proved that transplantation of incubate DAFB ultimately allowed shortening in 1.5–2 times the duration of burn wounds healing, prevented the formation of rough scars.

Experimental work was performed in three groups of rats. First control group was exposed on low altitude (760 m) with normal radiation background. Second control group was exposed on high altitude(2500 m) with normal radiation background and third experimental group were investigated on high altitude(2600 m) with increased radiation background(35-36 mR/hour). The results of the investigation showed that hemostasis of rats in experimental group changes much more toward hypocoagulation compared with control rats. In the experimental group, hemostasis of rats after 15 days of exposition showed maximal changes, after 30 days –average changes, and after 45 days - minimal changes.

It was studied efficiency of polyunsaturated fatty acids, presenting in omega-3 on restoration of estrus cycle in female rats. In rats of comparing group, taking low carbohydrate food and omega-3 we observed restoration of estrus cycle, there was many keratinocytes in vaginal smear. Low carbohydrate diet and omega-3 can restore estrus cycle in rats with experimental polycystic ovaries.

It was performed review of sources, devoted to pathogenesis of polycystic ovarian syndrome (PCOS). Modern scientific sources describe theoretical and clinical aspects, supporting connection of insulin resistance and PCOS, as well as metabolic changes. Further research, directed on clarification of molecular and genetic mechanisms of PCOS, can leads to new theories of etiology and pathogenesis, which can explain variety of manifestations in PCOS.

As a result of a research it is shown that a membranozny nephropathy, focal segmentaryglomeruloskleroz/gialinoz and the minimum changes are characterized by dystrophic and sclerous processes. At these morphological options of a there are no inflammation signs, and it is necessary to carry them to not inflammatory glomerulopatiies.

The main morphological changes in the scrapings of the endometrium in spontaneous abortion within the time 5-8 weeks in women with gynecological chronic infections are inadequate development of the spiral arteries, impaired differentiation of chorionic villi, slowing the process of decidualization endometrium, and violation of invasion of cytotrophoblast.

Particular qualities of quantitative structure of oral cavity microorganisms and its pathological changes presented in the article. The frequency of occurrence of different microorganisms (streptococcus, staphylococcus, lactobacilli etc.) and the change of their quantity depending on smoking is described. The role of microbial association in the nonspecific defense of mucous membranes of oral cavity is described. Also role of exogenous chemical factors to protective function of saliva are eluciated - tobacco smoke.

The article presents results of evaluation of neurophysiological parameters in 100 teen agers 16-22 years old, living at an altitude of 3000 m above sea level in Naryn region. The results are analyzed EEG studies neurophysiological parameters, status, involved in the formation of adaptation mechanisms and non -  physiological criteria Adaptive voltage level, clarified the limits of tolerance in a State of functional systems with the definition of health risk factors.

As is well known when the primary cancer is localized on the vocal folds, the patient's complaints were limited to the clarification of onset of the tumor, which appeared disorder fonatory functions. The latter is gradually growing, but is clearly manifested in the development of I stages of cancer. However, the violation is recorded voices and in many other diseases of the larynx. Therefore, the detection of the symptoms output required laryngoscopy before making a definite diagnostic had been done.

Investigated the nature of lung lesions (unilateral, bilateral) and the prevalence of the process (upper, middle, lower lobes, all of the shares) in the primary, hematogenous and secondary tuberculosis on autopsy material RPAB during the period from 1984 to 2008. Over the study period shows a significant increase in cases of bilateral lesions, especially in secondary tuberculosis. When a unilateral lesion in the process often involved isolated upper and middle lobe, and with bilateral lesion characterized by the involvement of all lobes of the lungs.

Involvement in the process of the kidneys in patients with subacute myocarditis has insufficiently studied. The clinical picture is nonspecific and asymptomatic myocarditis complicate a true assessment of the prevalence of the disease in the population. This article presents a rare clinical case of acute kidney injury in a patient with subacute myocarditis. Acute kidney injury was a consequence of low ejection fraction of the left ventricle, leading to inadequate perfusion and reduced renal blood flow.

Despite the stabilization and reduction of the main epidemiological indicators of tuberculosis in Kyrgyzstan, among children and adolescents, the most vulnerable groups of the population, the situation remains worrisome. Phthisiopediatricians work isaimed at the early detection of TB, in particular, its pre-local manifestations. The problem of differential diagnosis of post-infectious during allergy skin test sample contributed to the relevance of setting diaskintest 4370 children and adolescents from 1-15 years Bishkek and Chui region. Of all surveyed age groups, the results of positive samples diaskintest in 707 (16.2%), Doubtful – in 67 (1.5%) children, negative – in 3596 (82.3%) cases.

This study presents MTHFR folat metabolism gene gene C677T polymorplism in 20 complete (father, mother, clild) and 10 incomplete (mother, clild) families, where child had any neural tube defect as Spina Bifida or in conjunction witl malformation (total 80).

In this research work, the analyses of 42 history labors in pregnant women with tuberculosis, current of pregnancy and the obstetrical and perinatal outcome in the tuberculosis infected pregnant women was dan. Tuberculosis of the lungs identified in 76 % cases, in 11 % cases identified the extra lungs tuberculosis. In 41,4 % founded the positive discharged the mycobacterium of tuberculosis. Tuberculosis was detected during this pregnancy in the first time in 57,0 % cases.

This article presents a retrospective analysis of birth stories of women with macrosomia. Spend a literary analysis, studied the frequency of macrosomia, predisposing factors for the development of a macrosomia, childbirth and the postnatal period.

We examined 132 children under 3 years living in the southern region of the country (Osh) dysentery patients, hospitalized to the city infectious hospital. Etiological factor is updated in every second patient, the disease most often caused by Shigella flexneri, proceeded in a severe form with formation of extinderii and complications on the background of anemia, which was diagnosed in 70.4% of children. Need to search for effective methods of laboratory diagnostics.

The article represents the clinical analysis of cases of infantile cerebral paralysis in children born in the marriage between close relatives.

Studied the role of bacteriological flora in the development of acute obstructive bronchitis (AOB) in 94 children in the first 3 years of life and sensitivity to them to select effective antibiotic therapy.

The article presents the analysis and monitoring condition of children and adolescents with DM type 1 and assessment of the effectiveness of insulin therapy and educational programs was performed.
A prospective study of the dynamics of clinical status and effectiveness of combination therapy in 376 children and adolescents with DM1 was conducted.
It was confirmed, that there is the correlation between the decline in the number of patients MD1 hospitalized with Ketoacidosis and
patient’s education in the school of diabetes in endocrinology Department. Differentiated instruction has helped to reduce the frequency of Diabetic Ketoacidosis with 0.37 to 0.28 cases per patient per year.

It is necessary to recognize the revealed motivational motives as factors, creating a favorable background for development of a periostit. To some extent all of them are inherent also in representatives of the compared group, and it suggests, as they potentially are under risk of a disease the periostity.

The aim of this research is to study the modern clinic of intolerance to metal teeth prostheses and the state of cellular and humoral immunity in examined patients. There were examined 73 patients with intolerance to prostheses from chromium - cobalt and chromium – nickel steel alloys. The age of patients were 20-50 years. 31-men, 42- women. Clinical, immunological indices were studied. It was found that in patients with intolerance to metal dentures, there is some reduction in the cell and a decrease in the content of immunoglobulin A, M when using the prosthesis for 6 years.

The studies of stomatological status and nutrition were examined from the students of 1st and 2nd courses of Kyrgyz national military liseum named after D. Asanov. One of the reasons of studies is unrational and unhealthy eating with vitamins and minerals.

To determine the condition of the oral cavity in patients with nephrolithiasis, we performed dental examination of 30 patients with urinary stone disease in Urology Center of the National Hospital of the Ministry of Health of the Kyrgyz Republic, at age of 18-78 years old. The comparison group included students from the Dentistry Department of KSMA in the same number. A comparative analysis of the oral cavity in 2 groups revealed that with urinary stone disease, there are more severe changes in the hardtissues of the tooth and parodontium.

Based on the results of 4-fold examinations of 57 patients in the first 6 months after myocardial infarction it was established the efficacy of cardiac rehabilitation as a physical trainings at the bicycle ergometer.

The aim of the study was to present the results and to develop tactics of transcatheter correction for patients with aneurysm of atrial septal. The transcatheter correction was done for 21 patients. The age of the patients was from 4 to 46 years. According to Echocardiography the length of ASD was 19,9+-1,3mm(from 8 to 28,9 mm), and its size to atrial septal was 0,46+-0,04. The total size of defects in the aneurysm was 11,3+-1,4 mm( from 3 to 26 mm), and the stretch diameter of the largest defect was 12,9+-1,6 mm( from 4 to 24 mm). The size of occluders were from 6 to 35 mm, average 20,5+-1,8 mm, with length of atrial septal 12,9 +-1,6 mm (from 27,4 to 51,8 mm). The occluder type was determined according to the classification of P.Ewert and coauth., and also according to the defect size, the aneuryzm of atrial septal and its bulging. All cases of transcatheter correction were adequate without complications. So, the presice assessment of anatomic features of atrial septal by ECHO with determination the size of aneurysm and its bulging amplitude is nessessary for adequate transcatheter correction of complex formation anomalies.

The clinical functional and anatomic features of congenital heart diseases were presented in the article for patients with the multiple ASD, and also possibility of adequate transcatheter correction of this contingent with occluder Amplatzer. Successful implantation of this occluder was done for 15 (93,7%%) from 16 patients, 14 patients had two defects and 1 patient had 3 defect. The Stretch diameter of the largest defect was 18,5+-2,1 mm (from 6 to 35 mm). 1 occluder technique was used for 14 patients and only in one case- with 2 occluder technique was used. Precise assessment of anatomic features of ASD is necessary for adequate correction of multiple defects, especially amount of defects, distance between them, localization and complince of ASD.

There were many studies about the natural history of atrial septal defect (ASD) after introduction of non-surgical treatments. The natural history of ASD is favorable, but it was showed that the defect increased in diameter by time. The degree of shunting is determined by the size of the defect and the compliance of interatrial septum. This leads to the thinning the edges of the defect, in some cases there were disappearing of the edges, as a result it was changed the morphology. It was necessary to know that large defects without edges couldn’t be closed by non surgical methods. This shows that the monitoring on ECHO of all defects was necessary during 18-24 months after diagnosis.

This article describes an optimized mechanical endocapsular phacofragmentation by ultrasonic phacoemulsification cataract . 22 patients were operated with varying degrees of hardness of cataracts using mechanical endocapsular phacofragmentation . In terms of monitoring up to a month good visual function and the absence of complications were observed in all the eyes.

Новый способ профилактики прогрессирующей близорукости

In this research work presented the results of investigation the 262 history diseases of patients with chronically purulent media otitis which admitted to the ENT – department during the 1 year. The patients in 15,6 % cases had cholesteatomas, which was done the radically cleanings operations. Patients with cholesteatomas, in 9,9 % had epitympanitis and 5% epimesatympanitis. In patients with cholesteatomas in 0,7 % cases had the gigantic sizes the cholesteatoma. Presented for the example the clinically cases.

Shows the results of treatment in 127 patients with acute pancreatitis using programmed therapy according to the degree of gravity of endotoxemia. Complications occurred in 8 (6.3%), mortality rate of 0.7%.

The article is devoted to the optimization of diagnosis increased intra-abdominal pressure syndrome in patients with intestinal obstruction. In NHTS analyzed 150 patients with acute intestinal obstruction. Patients divided into 2 groups. The first group of 62 patients operated on for intestinal obstruction who underwent treatment algorithm developed by the prevention of thromboembolic complications. 50 patients we re the control group was carried out standard treatment.

The aim of this study was to determine the effectiveness of the prevention of suppurativevoospalitelnyh complications of abdominal surgery. In the process, we used clinical parameters, which included an evaluation of the general condition and the wound process (normalization of body temperature, the disappearance of pain) and ehomorfometriyu wounds over time.
We observed 100 patients who had used Dekasan- fungicide, prostotsidny, virusocidal and antimicrobial agents. International name of the drug manufactured by pharmaceutical company "Jury-Farm." The drug is used in the form of a 0.02% solution: at the time of the operation, after the main phase of the operation and the wound presenting abdominal organs Dekasan irrigation solution with an exposure of 5 minutes.
Dekasan used in 100 patients have acute cholecystitis in 41, acute appendicitis in 56 and one observation were patients with acute intestinal obstruction, strangulated femoral hernia and a ruptured stomach ulcer.
The postoperative period was complicated in 4 patients (4%) of these festering wounds occurred in 2 and nifiltrat another 2 patients. Our results show the feasibility of using Dekasana prophylaxis.

Оценка патогистологических изменений паравертебральных мышц у оперированных больных с грыжей межпозвонковых дисков поясничного отдела позвоночника

Explored the role of highly informative and radiation techniques in the diagnosis of early and late complications of patients after lumbar microdiscectomy. It defines the role of the prevention of scar-adhesions to improve the results of surgicfl treatment of this pathology.

We observed 503 patients with various urological diseases , which were divided according to severity of endogenous intoxication . Based on these results detoxification composed algorithm of this category of patients .

Миелодиспластический синдром