Vol. 6 No. 6 (2017): VESTNIK of KSMA

Summary. The authors performed sialendoscopy in 17 patients with salivary stone disease and presented a preliminary report. It has established that the possibility of simultaneous surgical intervention on the duct system makes sialendoscopy a method of choice for diagnosis and treatment of salivary gland diseases. The method has limited capabilities in the presence of a narrow mouth and narrow ducts that limits the indications for its use. Sialoscopy is a technically complex procedure that requires organized and consistent training.

Summary. The authors conducted a study of biopsies of small salivary glands in 15 patients with various diseases of the cardiovascular system. It was found that in patients with diseases of the cardiovascular system, there are pronounced and various pathological changes in the small salivary glands. They have expressed by a violation of the secretory activity of sialocytes, sclerosis of the stroma, lymphoid and lymphomacrofagal infil­ tration of the stroma and / or parenchyma, microcirculatory disturbances and dilatation of the ducts. The degree of severity of the detected pathological changes depends on the form of sialadenite. The study of sections of biopsies of small salivary glands has carried out in 15 patients with diseases of the cardiovascular system. It has found that in this category of patients there are different histological changes from the small salivary glands, characterized by impaired secretion, sclerosis and lympho-macrophage stromal infiltration, microcir-culatory disorders of the organ.

Summary. Study of clinical-laboratory indices in patients with sialadenosa occurring on the background of hypogonadism, showed the presence of objective xerostomia due to violation of the secretory function of the salivary glands. The viscosity of the saliva has also enhanced by the significant hypertrophy of the parotid glands. The concentration of sex hormones in the mixed saliva depended on the conduct of hormone replace­ ment therapy hypogonadism: if it has held, that the levels of free testosterone remained within the normal range, the concentration of dehydroepiandrosterone (DHEA) increased the contents of cortisone on the con­trary decre-ased. It was noted clinical improvement on the part of sialadenosis, however, full recovery not observed. If replacement therapy has not carried out, the content of melatonin, cortisol and DHEA in the saliva were not changed, the concentration of 17-Oh - progest-Ron of free testosterone and cortisone decreased. The data obtained suggested the need for a comprehensive examination of patients with sialadenosis occurring on the background of hypogonadism, an endocrinologist and a dentist for developing parameters of complex treatment of patients.

Summary. The problem of making a correct diagnosis for temporomandibular joint (TMJ) diseases is un­solved. A huge number of diagnostic methods (clinical and paraclinical: instrumental, x-ray, laboratory) used in various TMJ disorders, do not allow to fully differentiate it diseases. So one of the leading diagnostic meth­ods is multislice computed tomography.

Summary. The predominance of the clinic of maxillofacial surgery of patients with anxiety and obsessivephobic psychosomatic condition (37.82%) justifies the need for special treatment of psychosomatic, as a ra­tional therapy, prolonged sedation, antidepressants, tranquilizers, drugs that increase blood clotting, antioxi­dants, non-steroidal anti-inflammatory agents and antibiotics. The use of timely and adequate correction of psychosomatic condition makes it possible to avoid the development of hypertensive states in the pre - and intraoperative periods in 91.6% of cases, reduce the number of postoperative hematomas - by 22.38%, wide­ spread swelling and intense pain response - at 29.75% and severity of local inflammatory reaction in general, 89.51% of patients that ultimately contributes to optimize the conditions for wound healing and scar formation in full aesthetically in 62.68% of cases.

Summary. Preoperative examination of patients admitted for the purpose of plastic surgery in most cases does not allow obtaining accurate prognostic information about the outcomes of surgical treatment and possible complications. The aim of the study was to analyze the causes of complications in the early postoperative period in patients after plastic surgeries in the maxillofacial area. Based on observations of 211 patients oper­ated at of Oral and Maxillofacial Surgery Department No. 1 of the City Clinical Hospital No. 5 of Almaty, for the period of 2012-2015, an analysis was made of the causes of the complications in the early postoperative period in patients after plastic surgery in order to identify the possibility of predicting taking into account various “risk factors” using discriminant and regression analyzes.

Summary. There has shown the dynamics of changes in the content of lactoferrin and middle molecular peptidesin secret parotid glands at patients with chronic parenchymal sialadenits an exacerbation of the disease and in remission, depending on the stage and activity of chronic inflammation. It has found that patients with this disease it is advisable to monitor the content of biochemical parameters that can be used as an integral indicator of inflammatory and metabolic disorders in the salivary gland, and in order to correct the treatment.

Summary. An X-ray and morphological pattern of the course of reparative osteogenesis was studied in the obtained model of experimental periodontitis in rabbits with plasty of the postoperative bone cavity with a composite graft based on bone collagen, hydroxylapatite and autologous stem cells

Summary. The increased incidence of inflammation in the salivary glands determines the need to find new costeffective therapies, one of which is a step-down antibiotic therapy. The aim of the study was to evaluate the effectiveness of the step-down antibacterial therapy with the use of "Ceftriaxone" and "Clarithromycin" in the treatment of inflammatory diseases of the salivary glands in children in terms of pediatric oral and maxillofacial surgery to assess the dynamics of the inflammatory process compared general clinical blood parameters, body temperature, severity of general condition, local clinical picture, the features of inflammation in patients with acute sialoadenitos, exacerbation of chronic calculous sialoadenita and sialoadenitis. Analysis of the results of the study showed that the use of antibiotic therapy to speed "Ceftriaxone " and "Clarithromycin" in the complex therapeutic measures in patients with inflammatory diseases of the salivary glands leads to recovery without changing the length of hospitalization, but must consider the individual characteristics of the inflammatory response in the child.

Summary. Purpose of the report: Introduction doctors to clinical manifestations of myofascial symptom against the background of compressio-dislocational disfunction of temporo-mandibular joint (TMJ). 137 patients with compressed-dislocational disfunction of TMJ were examined, 13 among them had symptoms of paresis of mimic muscles. Diagnostics of compressio-dislocational disfunction of TMJ has based on spot-film radiography of TMJ, electromyography of chewing muscles by common methods. Based on the results of the researches the mechanism of occurrence myofascial symptom has performed, appurtenant local overload one of the joints, accompanied by compression of the anterior superior ear-temporal branch of the facial nerve, which has manifested by the symptoms of paresis of mimic muscles. The establishment of the causes of combined musculo-articular dysfunction TMJ and myofascial disorders will provide an opportunity to provide adequate treatment of these patients.

Summary. The aim of this publication is to analyze data on the pathological changes developing in salivary glands at IgG4-related disease (IgG4-RD) and pSS (clinical, laboratory, histological and immunohistochemistry signs).
From 2004 to 2013 289 patients with enlarged parotid and submandibular glands have been inspected. Among them 32(11%) patients IgG4-RD were diagnosed. 3 (9%) patients had IgG4-RD sialadenitis only, whereas involvement of a few organs ran as an IgG4-RD systemic disease in 29(91%).Two groups of patients with IgG4-RS( n = 32) and pSS (n = 57) have been compared and diagnostic algorithm offered. The determination of blood IgG4 (>2 g/l) in patients with enlarged parotid and submandibular glands may suggest the presence IgG4-RS. Morphological and immunomorphological examinations of major salivary gland biopsy should be performed. More than 40% of plasmatic cells secreting IgG4 – antibody evidence to IgG4-RS development.

Summary. For the purpose of definition of efficiency of a surgical method of the offered techniques of con­servative treatment sialolithiasis parameters microcirculation salivary glands by a method laser dopplerian-floumetria are investigated at method surgical treatment (14 patients), conservative - 18 patients (with use «Сапейюп N» on 50 кап. 3 times day, treatment spent solution KI 3% on 1 item to a spoon 3 times day, infusion of grass «Poligonumaviculare L.» on 1/4 glasses 3 times day within 4 weeks, a course combinations of the general conservative therapy with intraductarelitolisis with saliva autoparotidis salivary gland repeated in 6 months) 7-10 prosedurse daily (36 patients). Studying of dynamics of microcirculation is spent in 6 months
after the treatment. Statistical processing is spent with use of nonparametric methods. It is authentically estab­ lished, that optimum influence on parametres microcirculation renders the general conservative treatment in a combination with intraductarelitolisis (р<0,03). Carrying out only a surgical method insignificantly improves a microcirculation condition in salivary glands (р<0,05).

Summary. Damage to soft and bony tissues, in particular in the maxillofacial region, often leads to death in patients with hemophilia due to severe prolonged and difficult-to-stop bleeding. Based on their experience, the authors pointed out the peculiarities of the clinical course of injuries in patients with bleeding disorders. It was pointed out that the hematomas of these patients dissolve well under the influence of hemostatic therapy, while the use of physiotherapy, vasodilating ointments and compresses is inexpedient. Medical measures should be conducted only in hematological hospitals under the supervision of a doctor-hematologist and maxillofacial surgeon.

Summary. The article presents the experience of creating a mathematical model of salivary gland diseases and its practical application in the hope of popularizing special knowledge among dentists of various profiles. Perhaps this model will serve as a prototype for creating expert programs in other areas of medicine.

Summary. This article shows the results of the epidemiological study of orthopedic dental status of the older population of Osh city. Epidemiological studies conducted to determine the prosthetic status and prosthetic needs of the population. The results showed that with increasing age grows the number of persons with com­ plete loss of teeth and their need for prosthetics. Among the 300 studied persons 247 (82.3 per cent) did not have any tooth and wore complete dentures.

Summary. То 30 patients after lower jaw resection with disarticulation (on the occasion of neoplasm) the defects wегеreplaced by vascularized autotransplants of the 2nd radius of pedis and vascularized fibula autotransplants in combination with titanium implants. In all cases positive results were received. The authors consider that microsurgery with vascularized fibula autotransplants in combination with titanium implants was an optimal wауto replace lower jaw defects after its resection.

Summary. The article describes the technique of creating a surgical navigation template for conducting dental implantation on the basis of cone-ray computer tomography data and the DDS-pro program, CAD/CAM technology with complete secondary mandible adentium.

Summary. The article presents a clinical example of the operation of dental implantation using a navigation surgical template in a patient with a full mandibular adentium.

Resume. Diagnosis and treatment of odontogenic cysts sprouted in the maxillary sinus cavity was carried out using computed tomography and tooth-preserving operation. The closest and long-term results of monitoring patients showed the effectiveness of the proposed methods of treatment.

Resume. For the prevention of traumatic maxillary sinusitis in 22 patients in the sinus cavity, a temporary catheter for drainage and drug administration has established. The immediate and long-term follow-up of patients showed the effectiveness of this method.

Summary. Chronic inflammatory periodontal diseases are an urgent problem, the treatment of which is a difficult task. A rich arsenal of methods and materials for periodontal treatment, which does not always guarantee the desired outcome, and some sometimes contradictory

Resume. Destructive forms of chronic periodontitis take a leading role in the structure of stomatological illnesses. Phytopreparation “Perugenol” which used for intracanal therapy improves clinical and roentgenographic evidences in the early and long-term dates of treatment.

Summary. The most common disease of the oral mucosa is chronic recurrent aphthous stomatitis, whose frequency varies from 5 to 50% of cases. The review presents data on studies characterizing the frequency and features of the course of diseases with phenomena of polymorphism of clinical forms and their resistance to various types of therapy.

Summary. The review is devoted to physiotherapeutic methods of treatment of chronic forms of periodontitis. The published literature data show that the most effective results are obtained by combining several physical factors. Also indicates the promise of using a complex of laser and magnetotherapy.

Summary. The article presents the results of empirical studies of treatment of chronic generalized periodontitis of moderate severity with the use of magnetic-laser therapy. Conducted the examination and treatment of 57 patients aged from 29 to 60 years. The right choice of parameters used in the treatment of chronic periodontitis of moderate severity contributes to the reduction of terms of treatment and prolongation of remission period.

Summary. The systematized review of literature is introduced about modern descriptions of early and remote complications with a high score of fractures facial bones. The types, causes and risk factors of development of consequences and complications of injuries of maxillofacial area are considered. The main approaches to the prevention of purulent-inflammatory and post-traumatic deforming scars are highlighted. These facts indicate the need for further comprehensive studies aimed at studying the frequency, structure and location of damage to the maxillofacial bones in modern conditions.

Resume. Authors proposed bridge-type removable apparatuses with Orthodontic screw, which intended for tooth bed formation and straightening of above staying inclined ones.

Summary. There have been investigated methods of chronic destructive apical periodontitis treatment with the use of a gold nano-solution, which is considered to be the most effective due to its reparative properties in conjunction with calcium hydroxide, influencing the fall of destructive loci in the apical part of  the root of a tooth.

Summary. The possibility of successful orthopedic treatment on two-stage implants without a superstructure has considered, with the manufacture of an individual pivot abdominal pin and the subsequent prosthetics.

Resume. This article presents information on the life activity of the honored scientist, Corresponding Member of the National Academy of Sciences of the Kyrgyz Republic, winner of the state awards of the USSR and the Kyrgyz SSR, Doctor of Medical Sciences, Professor Valentina Abdyldaevna Isabayeva.

Resume. During the Phase 1 clinical trials of the Sausalin drug, the safety of the drug on 30 healthy volunteers has proved. During the 2 nd phase of clinical trials of the Sausalin preparation, the quality of life was improved in patients and the UZ picture of DD was improved, while the absence of cysts of lamblia was determined during a coscan.

At present, permission has obtained and phase 3 of the clinical trials of the Sausalin preparation has started within the framework of the project "Study of the clinical efficacy and safety of the Sausalin preparation as a counter-lymbolism."

Resume. The article describes the methodology of qualitative analysis of drugs on the example of the public television and radio corporation (OTRK) of the Kyrgyz Republic. The conclusion about the prevalence of advertising of drugs that affect the gastrointestinal tract. In the analysis of drugs advertising in the countries-producers, the advertising of medicines domestic producers were absent. All analyzed advertising of drugs conforms to the official instructions for its use. Search information on the proven effectiveness of the advertised drugs from the Cochrane library showed that the majority of drugs do not correspond to the subject of evidence. In the analysis of ethical criteria, it was identified that the most important criterion as the criterion of safety (specifying the information about contraindications, precautions) advertising 2 medications out of 13 corresponded.

Resume. A comparative quantitative analysis of temporal and frequency characteristics of the time advertising of drugs on television, the Kyrgyz Republic, in particular the OTRK and the First channel of the Russian Federation. Shows the differences between the saturation advertising of drugs on the televisions of the two countries. The conclusion about the over-saturation of the Russian TV channel compared to the Kyrgyz television. The presence of a large number of advertising drugs on television were in the evening (Prime time).

Summary. Viral hepatitis D is considered the most severe form of viral hepatitis. Only 25% of patients respond to therapy. Chronic HDV infection leads to a more severe liver disease than chronic HBV-monoinfection and is associated with rapid development of fibrosis and an increased risk of hepatocellular carcinoma, as well as early decompensation of an already existing liver cirrhosis.

105 patients with chronic viral hepatitis delta were examined. All subjects underwent IL-12 levels, tumor necrosis factor alpha, IL-17, IL-10, transforming growth factor beta-1 in serum by ELISA (IBL (Germany)).

The results of the level study showed a significant increase in TNF-alpha, interleukin-10, depending on the stage of fibrosis. Levels of IL17, IL12 / 23, and TGFβ1 were elevated in patients with F3-F4 fibrosis in comparison with patients with fibrous stage F0-F2. Positive statistically significant association of the level of TNF-α and the level of intreleukin-10 with the fibrosis stage, with the level of ALT, AST and negative with values of creatinine, urea, platelets and leukocytes was found.

Summary. The efficacy evaluation of an antiseptic medicine 10% Povidone-iodine applying in the treatment of acute purulent inflammation of soft tissues during the adaptation to high altitude conditions in the experiment is given. The character of acute purulent wound processin experimental rabbits during the short-term and long-term adaptation to high mountains was studied at the 3rd and 30^thdays of staying at the Tuya-Ashuu pass (3200 m above the sea level).

Summary: presented results of relaparatomies in 32 patients caused by biliary leakage. Given the reasons of bile leakage after parasitic disease and cholelithiasis surgery. The complications were in 4 patients (12.5%), one patient died because of multiorgan failure (3.1%).

Summary. The article compares the results of surgical treatment of patients with fractures of the acromial extremity of the clavicle. In 66 (44,0%) patients of the main group, a new device for osteosynthesis developed in the clinic was used (Preliminary patent of the Republic of Kazakhstan for invention No.12149 dated 15.11.2002 “Device for treatment of dislocations of the acromial extremity of the clavicle”). The traditional fixation was used in 84 patients (56,0%). In the main group of patients, the frequency of good outcomes (84.6%) was higher than in the 1 and 2 control groups (71,0% and 57,5%) by almost 1.2 and 1.5 times (p <0.001). The positive outcome was achieved with use of a new device for osteosynthesis of the clavicle, which allowed to perform a stable synthesis, to perform early rehabilitation of patients, which created optimal conditions for fusion of the clavicle acromial extremity fracture in comparison with the traditional method.

Summary. The analyse of operative management results in 120 patients (70 – 58.3±4,9% male and 50 – 41.7±7,3% female) with neurological complications in lumbar disc herniations has been done. The management outcomes depended on great number of factors thoroughly taken in consideration and studied.

Summary. The results of the application of preventive measures in 42 diabetic patients undergoing surgery for abdominal diseases (main group) and the results of 52 patients (control group) using conventional preventive measures are provided. Complicating diseases occurred in 3 patients (7.1%) from the main group and in 9patients (17.3%) from the control group.

Summary. Authors have investigated 110 patients (220 eyes) aged from 16 to 78 years (male 78 (71.0%), female – 32 (29.0%) with closed traumatic brain injury treated in neurotraumatology department. Results of complex investigation of patients with traumatic brain injury has shown that hemodynamic changes in venous circulation precedes to papilledema, and absence of spontaneous pulsation central vena in the 2 and 3 days after trauma is early and pathognomic sign of intracranial hypertension.

Summary. Authors have investigated typical ophthalmological signs in patients with severe traumatic brain injury. 110 patients (220 eyes) aged from 16 to 78 years with closed traumatic brain injury treated in neurotraumatology department. Among them male 78 patients (71.0%), female - 32 (29.0%). Results of complex investigation of patients with mild traumatic brain injury has shown that character of injury causes long-term disorders of cerebral and orbital microcirculation, and pathology of neurophysiological processes in the brain cortex and optic analyzer. 

Summary: Analysis of the 1417 conclusions of the examination in 2005-2009 showed that death from traumatic brain injuries occurred in 346 affected, accounting for 24.42% of which 77.17% in the death rate from TBI Presley to that of men, at 22.87% are women. At the age of 16 to 55 years (working age) death from traumatic brain injuries accounted for 298 cases, and in 70.23% of cases, from traffic accidents. Ethyl alcohol in the blood of the dead from a brain injury was found in 36.12% of cases.

Summary. This article provides an analysis of mortality working-age population of Osh oblast and Osh from violent causes of death in 2000. It was found that the materials of the Osh regional bureau of forensic medical examination revealed a violent death in 131 cases out of 177 cases of utopian material in 72 cases (54.9%) caused the death of the working population were the mechanical trauma in 48 cases (36.6%) and mechanical asphyxia poisoning. The ethnic composition of 41.2% of the victims were ethnic Kyrgyz, 35.1% - Uzbeks. In the Kara-Suu district of violent death was found in 38 victims, including 35 cases (92.2%) the cause of death was mechanical injury, mechanical asphyxia.

Resume. Comparative evaluation of effectiveness of the liver protector “Antral” in complex treatment of hepatic steatosis in children suffering metabolic syndrome has shown. The drug could be recommend for inclusion in the complex treatment of metabolic syndrome to prevent progression of hepatic steatosis.

Resume. In rural areas, most mothers have adequate knowledge of the importance of breastfeeding, but not all of them follow their knowledge, since every tenth newborn begins to receive supplemental nutrition already within the walls of the maternity hospital. More than half of children aged 6 months to 2 years do not receive an acceptable variety of products per day, every third child - in the minimum allowable multiplicity of food intake within a day.

Irrational, mostly nutritional deficiency is the cause of high prevalence of iron deficiency anemia (44.7%) and stunting (15.9%) among children aged 6 months to 2 years.