Vol. 1 No. 1 (2017): VESTNIK of KSMA

Resume. This paper gives information about the life and activity of the outstanding physician of the Kyrgyz Republic, National Academy of Sciences academician, laureate o f the state prizes o f the USSR and the Kyrgyz Republic, the doctor of medical sciences, Professor Mirsaid Mirkhamidovich Mirrakhimov.

This article deals with study o freactions of specific lysis of leukocytes and levels of potassium ions in patients with drug allergies, and in the control group of healthy individuals without allergy anamnesis.

Using Y.pestis capsular antigen and conjugate based on protein A Staphylococcus, labeled with horseradish peroxidase highly sensitive and specific IEAtest system for the detection o f antibodies to capsular antigen is developed. In contrast to the EIA test system with use of a conjugate based on antibodies againsthuman IgG EIAtest there is developed universal system and it detects antibodies, not only in humans but also in different animals. The sensitivity of this EIA test system is higher than the specificity of the reaction of a straight line o f gems agglutinations. In the study of immune sera against the 5 other bacteria there is shown its specificity. A test system was stable for 6 months after production (observation period) and can be used to assess the post-vaccination immunity in humans and camels immunized against plague, as well as to assess the dynamics o f antibody response in model experiments on immunization and infection of laboratory animals and evaluation seropositive animals in the monitoring of natural foci o f plague. 

The aim of our work was estimation of vegetative-nervous system functional state of service men - inhabitants of lowlands, working in highaltitude under the influence of musicatherapy of ethnic kyrgyz trend. We were to define the influence of ethnic kyrgyz music using national instruments, such as komuz, ooz-komuz on the tone and reactivity of vegetative nervous system. 23 servicemen at the age of 18-22, natives of lowlands working in the city of Naryn (the height is 2679 m. over sea level) by the method of spectral analysis of cardiac rhythm were analysed.The results showed, that they had parasympathic variant of vegetative reactivity to orthostatic probe.

This article presents the results of comparative studies of healing purulent wounds, in the treatment of wounds with ointment "Levomekol" during the period of readaptation to the highaltitude after 3 and 30 day staying on the pass Tuya Ashuu in experiment. There are established the best indices of healing in a group of animals after 3-days stay at the altitude 3200 meters and the worst index in the group after 30-days staying at the high altitude. The evaluation is based on the results o f the dynamics o f general and local clinical pictures, quantitative and qualitative microbiological tests, cytology of wound prints and planimetric studies.

The history of the creation and development of occupational pathology services in Kyrgyzstan is described.

This review focuses on the cardiorenal syndrome type 1.This review focuses on the cardiorenal syndrome type 1.

The aim of study is to study the efficiency of outpatient treatment of patients with essential hyper­ tension. Methods: the retrospective analysis of the out-patient cards containing information on drug treat­ ment of patients with an idiopathic hypertensia on the basis of the center of family medicine № 3 is carried out, survey in an oral form and anonymous questioning is conducted. Results and scientific innovation: as a result of the carried-out questioning the majority of patients is satisfied by the quality of help given them by the specialists of the center of family medicine №3. The most appointed medicines are inhibitors, beta-blockers of receptors of angiotensine.

The risk factor (RF) can influence on the spreading Неlicobactег pylori infection. We have exam­ined indigenous people of Kyrgyzstan with duodenal peptic ulcer, the risk factors prevails standard of living below average, low level of education, impurity, or limited access to water. These RF are spread in the Batken region.

We observed 65 patients with chronic gastric in the condition of full or median remission, we treated these patients by means of current and mud therapy, mineral water and medicated preparations. We see positive dynamic of illness and good tolerance of used treatment methods.

Hygienic assessment of the military lyceumstudents’ nutrition for 2 years (2014-2015) showed qualitatively seasonally malnutrition - inadequate consumption of animal proteins, excess consumption of vegetable fats and increased consumption of carbohydrates for all seasons.

There was investigated etiological structure of acute intestinal infections in the Kyrgyz Republic.

In our database of National Hospital under the Ministry of Health of the Kyrgyz Republic of the Department of neurosurgery since 2010 to December 2015 there were 708 cases of neuro-oncological patients with primary central nervous system tumors of different malignancy grade 0-IV. There were investigated sex and age features and long-term results of surgical treatment of patients for determining their overall survival. It was established that the five-year survival indicators in grade IV are above in relative the second group.

This article presents the results of studies of the value of CNS neoplastic lesions in 802 cases of neuro-oncological patients treated at the National Hospital of the Ministry of Health of the Kyrgyz Republic Neurosurgery depatrments, for the period from 2010 to 2015. It was found that the value of CNS tumors
significantly higher among residents living in areas of uranium tailings, regarding patients outside the zone of uranium tailings. The main factors determining the origin and direction of dislocations and herniation of the brain, is the volume of the tumor mass, the pace of development and the propagation path.

There were examined 44 patients to analyze the quality of life (QOL) of epilepsy patients with different variants of anti-epileptic treatment. It was found out that high scores on all subscales of the QOLIE31 have been observed in patients receiving polytherapy and lamotrigine. The lowest values of QOL scales
were in patients on carbamazepine and valproate therapy.

This article presents the clinical experience and observation of successful treatment of nonclostridial anaerobic cellulites of the upper limb and the right side surface of the chest and abdomen.

On the basis of evidence-based medicine methods it was determined the effect of prophylactic drainage of the abdominal cavity after surgery on the distal parts of the gastrointestinal tract through the collection, interpretation and integration of reliable, critical and applied in practice, evidence obtained in special
medical research.

on the basis of evidence-based medicine methods it was determined the effects of prophylactic abdominal drainage after appendectomy.

this article deals with antibiotic resistance, which shows to world medicine community new re­quirement of rules in using antibiotics in clinical practice. Structural and pharmacodynamics features of Moxifloxacin - representative VIth class of fluoroquinolones - consider as a drug which fully conform to
modern clinical criteria’s of antibiotics in treatment in pluripotential infectious diseases. This article shows results of some multicentrical clinical researches using Moxifloxacin, and considers the questions of using this drug as a medicine of second line in treatment tuberculosis of respiratory system.

the aim of this work was to improve the results of treatment of liver alveococcosis. The survey used laboratory and instrumental methods of examination. There were observed 59 patients with alveococcosis, in 3 patients the process is recognized as inoperable, in 19 it was performed radical operations and in 37 it was performed conditionally radical operations with cryodestruction of the left foci alveococcosis. The postoperative course was favorable. At discharge there were given 3 courses of chemotherapy with albendazole 400 mg for 28 days to prevent recurrence of the disease. In terms from 6 months to 2 years study included 29 patients from 37, 12 - the examination revealed a lesion with clear contours, at 8 - no change 9 -the lesion decreased in size, neither not detected a progression of the process. Repeated operations were performed in 11 patients, 9 veluwen the lesion, and at 2 a part of the site which was not possible to remove the treated with liquid nitrogen. The postoperative period was uneventful. The obtained results confirm the effectiveness of the use of cryodestruction in conditionally radical operations. One patientdied from multiple organ failure.

Authors analyzed postoperative complications, clinical features, significant prognostic factors, results of surgery and rational treatment tactics in postoperative complications of meningiomas have been reviewed. Consequently 202 patients with histologically identified meningiomas have been operated. Postoperative complications were identified in 20 cases.

The results of the study are based on 140 cases of nontraumatic supratentorial bleeding (males 82, females 58). The group of surgical treatment consisted of 59 cases. The second group was presented with 81 cases underwent conservative management.

The research objective - studying of data of complex inspection at a longitudinal dislocation at the craniocerebral injury (CCI) with a quantitative assessment the degrees of infringement of a brainstem in the tentorium cerebelli (TC) and the foramen magnum (FM). Complex clinical and beam examination of 92 victims with the CCI in the acute period conducted. Complex inspection included neurologic survey, an assessment of extent of violation of consciousness on the scale of a coma of Glasgow (SCG), ultrasonography of the head, chest and abdomen cavities, CT and MRI. Based on the conducted examination 92 victims, the most part (58.7%) from which - in the first 6 hours after an injury operated on.

On CT or MPI of a brain in the axial plane measured the area of a FM (S1). Further determined the total area of the tonsils of a cerebellum (S2) displaced in FM with the subsequent calculation of coefficient (Co) infringement of a brainstem in FM by a formula: Co=S2:S1*100%. At value of coefficient of infringement of a brainstem in FM to 20% degree of infringement counted moderate, at value of an indicator from 21 to 30% - expressed and at coefficient of infringement of a brainstem in FM more than 30% - considerable. Degree of the visualized dislocation formed the basis for terms and volume of surgical treatment.

We performed a retrospective analysis of outcome in patients with severe head injury treated at the National Hospital of the Ministry of Health of the Kyrgyz Republic and the medical centers "Koy-Tash" and "Zdorovie". In the study period, the patients were divided into two groups: the first study period-from 2010 to 2013 and the second - in 2013 and 2016. In the first and second periods of the study there were varied parameters control the state of the body and brain functions, methods and goals of therapy. Increasing signs of axial and lateral dislocation as we move from type I to IV diffuse injury mind associated with an increased detection rate and severity of intracranial hypertension (ICH). In the second period study ICH was found in 25% patients with the II type of damage, 57% of patients with III type and 80% with IV overlooking damage. The mean intracranial pressure (ICP) in the affected group II with a type of diffuse injury was 14,4 ± 6,6 mm Hg, with a type of damaging III - 30 ± 20.6 mm Hg, with a type of diffuse injury IV - 37.6 ± 14.1 mmHg The introduction of the differentiated approach to the application of conservative and surgical methods for the treatment of severe diffuse brain injury based on ICP monitoring data has resulted in a significant decrease of 22,9% mortality during the second period of the study compared to the first period of study.

Intracranial complications occured after suppurative inflamation in the middle ear apply to very difficult diseases. The patients with intracranial complications, as a rule, are hospitalised in ENT and neurosurgery in-patient departments because surgical treatment is nesessary in a first stage. Practical work shows that ENT-specialists have troubles in veryfication of intracranial complications, especially combined. For clear diagnosis and treatment of above-mentioned diseases it is nesessary have a knowledge not only in neurological syndromes, but in understanding all conditions of their appearance.

Prevention of persistent hearing loss of children with congenital cleft palate upper lip can be successful only if concerted action of ENT doctor, audiologist and maxillofacial surgeon. Simultaneous uranoplasty and tympanostomy lead to normalization of the function of the auditory tube, the normalization of the
aeration of the middle ear and mastoid cavities, respectively» relief of the causal factors of otitis media with effusion.

In our study there are studied and presented the results of influence of the different medical and social factors, leading to development of violations of reproductive system of modern teenage girls aged 15­ 18 years old of Bishkek city. The major factors that cause the main of menstrual dysfunction such as algodismenorrhea of girls senior pupils are given.

Results of research of features of physical and sexual development , the general and reproductive health of 15-18 years old pupils-girls of educational institutions of Bishkek city ( middle mountains zone - 760 m above sea level) and a high altitude zone - Naryn city ( 2048 m above sea level) are presented. Not favorable tendencies of formation of reproductive health, somatic and gynecologic incidence of teenage girls of the studied regions are revealed.

The main treatment for cervical cancer are surgery and radiation, the role of chemotherapy in this localization is not well studied. Chemotherapy is also used among patients with metastases in the pelvic and paraaortic lymph nodes with little chance of recovery by conventional methods. Moreover, anticancer drugs could be used as a modifier in combination with radiotherapy. Concurrent radiotherapy regimens are now becoming standard in the treatment of locally advanced process. During our research, among 58 patients with locally advanced cervical cancer, as a radio-modifier we used cisplatin 40 mg / m2 intravenously with hydration once a week during radiotherapy. Objective response was 77.6%.

Were conducted questionnaires to analyze the medical and social status of pregnant women with obesity, retrospective (171 stories) and prospective (147 stories), and analysis of social, domestic features, obstetricgynecological and somatic anamnesis. Index group- 198 women with abdominal obesity, control group- 120 women with standard weight. It was indicated, that among women with obesity, there were predominated patients over 30 years old, their nutrition was unbalanced and irregular, low physical activity was 61.1%. In obesity of II and III degrees there were menstrual disorders, gynecopathies and secondary infertility, extragenital diseases.

There were conducted prospective and retrospective analysis of 318 stories of newborns to examine the features of the state of newborns in the early neonatal period in women with obesity: 198- from mothers with obesity of varying severity, 120- with standard weight. In obesity of II and III degrees more likely than in the control it is registered an amniotic fluid aspiration (in 1,7 and 2,5 times), fractures of clavicle (in 3,1 and 6,2 times), cephalhematoma (in 2,1 time), congenital malformation of the fetus (in 4,4 and 6,6 times). Postnatal adaptation is complicated by the pathological course of neonatal jaundice (in 1,2 and 1,8 times), increased excitability syndrome (in 4,1 and 9,3 times), pathological weight loss (in 2,1 and 1,8 times). Thus, obesity in mothers exerts a negative influence to the status of newborns. 

The article deals with topical problems of prenatal diagnostic of the congenital malformation fetus. There was studied the possibility of ultrasound diagnostic of folat depending on congenital malformation. The results of 337 fetus with congenital malformations were presented. The congenital malformation were resulted in 174 fetus by ultrasound invastigation. High effective of ultrasound diagnostic on possible the folat dependind on congenital malformation were found. It has been increased the incidence of folat depending malformation on the years and summaries. The conclusion has been made on the possibility of ultrasound diagnostic of the main lethal forms of congenital malformations.

There were examined 138 early aged children and 182 children one to three years old with dysentery, who were hospitalized to municipal infectious hospital in Osh and nearby regions. Etiology of dysentery in early aged children was Sh. Flexneri. Dysentery caused by Sh. Flexneri in early aged children passed (P<0,05) in severe forms (82,6±3,5%; 65,4±3,2%) with complications. Durations of symptoms of dysentery caused by Sh. Flexneri had no significant (P>0,05) differences in early aged children and in children one to three years old.

In this work it was carried out the analysis of 47 case histories of illnesses of children who were hospitalized with a diagnosis of scarlet fever to the Republican clinical infectious diseases hospital (RCIH) in 2015 year. In the age structure of patients with scarlet fever there were predominant (76,6%) children of preschool age (from one year to 6 years). The diagnosis of scarlet fever was made in most cases (70,8% -89.4%) already in the prehospital phase on the basis of typical clinical signs of the disease. The moderate form (61,7%) of the disease was predominant. Complications occurred in 8,0% of patients with scarlet fever in the acute phase of the disease.

The analysis of the 65 case histories disease of infants, hospitalized to the Republican infectious clinical hospital in 2016 with a diagnosis of acute intestinal infection. Clinical and epidemiological parameters were used. The results of bacteriological examination of feces revealed that an important place in the etiological structure of escherichiosis of the I category are serotypes: O111, O55, O44, O126. There were escherichiosis, caused by enteropathogenic Escherichia coli among acute intestinal infections. Clinic of escherichiosis is manifested by gastroenterocolitis syndrome, gastroenteritis and enterocolitis syndrome, which does not exclude the probability of the presence of mixed infections. The disease was mostly severe (96.9%).

The problem of treatment of chronic periodontitis today is important. In order to reduce the number of exacerbations during and after the treatment paste used «Abscess Remedy Paste» and positive results in the treatment of infected root canals.
 

The research goal was to study the radiological symptoms of various diseases of dentomaxillofacial region based onto the cone beam computed tomography (CBCT). CBCT images of 2400 patients were analyzed. Densitometry of pathological areas has been performed in Hounsfield Units. The radiological symptoms of anomalies of the teeth and jaws; inflammatory and destructive changes of periodontium and periodontium; inflammatory changes in maxillary sinuses; cysts and benign tumors of the jaws; inflammatory, degenerative changes, subluxations and dislocations of the temporomandibularjoints;maxillofacial injuries andjaws malignancieshave been described. Utilization of CBCT visualizes the spatial location, distribution,
and characteristic of the pathological process more clearly which is important for determining of subsequent treatment strategy.

In recent years there is the acute problem of speech etiquette (especially among youth). Active youth lexicon consists of 300-400 words, of which 30-35 word-parasites do not carry any meaning. They can be considered as diseases transmitted by airborne droplets, because person can be “infected” by wordparasites by personal contact, often using this kind of words in his speech.
The article discusses the speech etiquette of medical students and the place of word-parasites in their speech. This research was conducted through questionnaires and audio recordings.
After the quantitative detection of words - parasites in speech of the future doctors, the waes of getting rid of
them and the to fight them was given in this article.
 

НАУЧНАЯ И ПЕДАГОГИЧЕСКАЯ ДЕЯТЕЛЬНОСТЬ ПРОФЕССОРА С.Р. РУЗУДДИНОВА (к 70-летию со дня рождения)