Vol. 4 No. 4 (2014): VESTNIK of KSMA

The objective of this reseach has been the study of immunotropic properties of the cryopreserved pig substrate (CPSS) in guinea pig in the experimental pathology, such as a contact dermatitis guinea pigs. The guinea pigs had a normal immune status. It has been defined, that prophylactic administration of CPSS to animals stimulates the phagocytic function of lymphocytes, has no effect on antibody response and inhibits the growth of DTH reaction. In terms of allergic dermatitis CPSS decreases the severity of inflammation and normalizes the level of immunoglobulins. These results indicate immunomodulatory properties of CPSS and make it appropriate for further study to create antiallergic agent for highly pathogenic therapy of allergic dermatitis.

Findings of peripheral blood and condition of marrowy blood formation of rat- males of the line Vistar from transplantable carcinosarcoma Walker-256 were investigated. Suspension of cages of transplantable carcinosarkoma Walker-256 entered into a hip muscle in a dose . For receiving serum of blood of rats it was made decapiting under a radio anesthesia for the 6th, 9th, 13th, 20th, 28th days of experiment from the moment of a tumor transplanting . For an assessment of indicators calculations of indicators of peripheral blood of rats were made. On all terms it was observed progressive decrease in quantity of erythrocytes and cells of marrow

The term “orphan disease” (rare diseases, Eng. Orphan disease) first appeared in January 1983 in the United States in making the law «Orphan Drug Act», designed to encourage pharmaceutical companies to develop drugs for diseases that have a small market. According to this law, companies that develop these drugs can sell them without competition for seven years and have tax credits for clinical trials. There is no single, widely accepted definition of orphan diseases. There is no single level of disease prevalence in the population, in which it considered a rare start.

In this report we present the results of a retrospective study of 149 cases of obstetric hemorrhage, with which it was traditional hysterectomy as primary surgical method to stop bleeding. By the end, we were divided into two subgroups - the survivors (98) and deaths (51) cases. Compared groups of patients were not statistically different in age, mode of delivery, obstetric and somatic anamnesis. In the end, death was observed in 34.2%. It should be noted that 72.6% of deaths occurred in the regional medical - preventive institutions.

Aim of the study was to evaluate the physical development of adolescent girls – residents of Bishkek. Data from 390 high school students in the age of 15,5+0,4 were collected to examine. Majority of examined adolescent girls have average height/age and weight/age indicators for their age (M±1σ). 9,9% of the girls have weight deficit, height deficit was identified in 12,4% of examined girls.

Results of research concerning social and psychological adaptation, predilection to sacrifice and the relations to life in persons with different type of brain lateralization are presented. Two options of adaptation in persons with dextrocerebral asymmetry are revealed: the expressed sacrifice and desadaptation; adaptation without sacrificial attitudes.

All dates indicate that the parasitic diseases reach high level in our Republic. It is jointed with agriculture and the poor level of personal hygiene of population. The children are amenable for those diseases, mostly. The deficiency of staff in parasitological works, remain as big problem.

In this article it is given sanitary - hygienic estimation of light exposure on educational audiences of KGMA and its influence on a functional condition of vision organ of students.

This work investigated the prevalence of cytomegalovirus infection in the Osh Region. There were positive findings among patients studied (6067), 4091 patients were IgG positive (67.4%), and 1976 were IgG negative (32.6%). Chronic cytomegalovirus infection was found in children (27.2%) and in adult patients (72.8%). Specific G class immunoglobulins were the most frequent marker that was detected in patients tested for cytomegalovirus infection.

Described the clinical features of acute respiratory viral infections in children with hypoxic ischemic encephalopathy in 36 children aged from 1 month to yaer

A comparative assessment of the effectiveness of antihelikobakterna treatment of children with gastroduodenal ulcer using antisecretory drugs from the group of proton pump inhibitors from different generations. First in terms of our clinic applied parenteral administration of pantoprazole to children, reducing the healing time of the ulcer and inflammatory activity.

The prevalence of health risk factors among students KSMA, KRSU.The sample included 837 university students from health sciences undergraduate. Mean age 21,3±1,5years. Students filled out a questionnaire to determine health risk factors. The study showed that medical students Kyrgyz universities, practicing unhealthy lifestyle.

An assessment of ultrasound examinations of 68 patients with post-traumatic origin orchiepididymitis.

In this work we studied cytokine concentrations of: Interleukin-1β (IL-1β), Interleukin-2 (IL-2), Interleukin-6 (IL-6), tumor necrosis factor (TNF), - confirming autoimmune origin of hemorrhagic vasculitis with violation activity of natural killer cells and cytotoxic lymphocytes. The obtained results show the effectiveness of the treatment of the therapy.

To assess the relationship between the decline in left ventricular systolic function in clinical and end-stage renal failure were examined 84 patients with chronic kidney disease (CKD). Found that patients with stage V CKD left ventricular sizes were significantly less than in patients with stage III-IV CKD, which was also accompanied by more expressed systolic dysfunction.

Research of 395 2-year-old children, inhabitants of Bishkek, full-term, with signs of intrauterine growth retardation (IUGR) at a birth is carried out – 257 children with hypotrophic variant and 138 children with hypoplastic variant. It is defined, that in investigated groups there is the raised infectious case rate and the metabolism disorders are registered and its frequency accrues with increase in degree of expressiveness of IUGR variants. The greatest infectious case rate is revealed in children with hypoplastic variant of IUGR.

The purpose of the research in the study of the causes and structures of severe preeclampsia. Retrospective analysis of medical records of 104 women admittedt to the emergency department in 2011 was performed. From diagnosis: severe preeclampsia. To assess the effectiveness of the protocols used indicators.

This review focuses on the analysis of features of the treatment of acute coronary syndrome in patients with renal dysfunction.

In worker is presented multisegmental endoprosthesis replacement of large joints at 19 patients at diseases of rheumatoid polyarthritis and illness Bekhterev’s with 2010-on 2013. Age range makes from 18 to 64 years. The results remote are studied on SOI-3.

The purpose of research is the study of amlodipine and lisinopril (еquator, Gedeon Richter, Austria) on circadian blood pressure monitoring (ABPM), echocardiography in patients with essential hypertension (EH). The study included 47 patients with EH II and III degree are at a dispensary in FMC №7 in Bishkek. On the background of a three-month course at a dose of 10 mg of the equator in the day according to ABPM, a significant decrease in both systolic and diastolic blood pressure. Reception equator reduced hemodynamic load on the left atrium.

To assess the relationship between the decline in systolic function of the left ventricle (LV) in patients with myocardial infarction (MI) with ST-elevation (STEMI) and myocardial infarction without ST-elevation (NSTEMI) 97 patients were examined. It was found that in patients with STEMI the ejection fraction of the LV was significantly lower than in patients with NSTEMI, which was also accompanied by a more expressed LV systolic dysfunction.

The object of the work was to study the neuroendocrinoimmune interaction in autoimmune thyroiditis in dependence of thyroid gland function activity. Clinical characters of disease, maintenance of the thyroid gland hormones, immune status, arterial pressure level, pulse rate, vegetative index by Kerdo have been taken into consideration. Fifty patients have been studied, and it was found that the disturbances of the neuroendocrinoimmune system depended on thyroid gland functional activity.

Analysis of treatment of 113 patients with fractures of the lower third of the shaft of the humerus, which held of plate osteosynthesis plate. Of these patients developed a way to access applied for fractures of the lower end of the shaft of the humerus, which eliminates the radial nerve trauma.

This article presents clinical and epidemiological peculiarity of parvovirus B19 infection in children defined by immune-ferment analysis (IFA).

This article presents the results of a study level of endothelial growth factor in serum by enzyme immunoassay in patients with chronic cardiac insufficiency in patients with coronary heart disease.

This article analyzed the long-term dynamics of morbidity, with assessment of epidemiological, clinical and laboratory situation on brucellosis in recent years. The analysis of case histories of 304 adult patients hospitalized to Republican Clinical Infectious Hospital (RCIH), with various forms of brucellosis revealed a high percentage of chronicity that provides the basis for evaluating the effectiveness of existing schemes of antibiotic therapy.

This work is devoted to the study of the regulation of erythropoiesis in patients with aplactic anemia during his stay in the highland hospital, at an altitude of 3200 meters above sea level. The presented data suggest that hypoxic hypoxia positive effect on a number of hematological parameters, normalizing erythropoiesis (increase in hemoglobin, EPO and HIF-1a).

This research work compared three methods of adjuvant chemotherapy (“dose-dense” chemotherapy in 2 modes, and standard method) in the treatment of breast cancer patients .
Objective: To evaluate the effectiveness of a “dose-dense” adjuvant chemotherapy in the treatment ofbreast cancer patients

The complex of developed innovative ways for treatment of boils (furuncles) and carbuncles maxillofacial using bacteriophage Pio «Fagio» and ointments «HYPOFUR» is given in this work.

This article presents the results of treatment of fractures of the condylar process of the mandible using immobilization Claw - Tooth rehabilitation tires with the addition of the drug calcium D3 Nycomed and electrovibromassage.

It is presented clinical experience of surgical reconstruction of bone defects in the dentoalveolar area of jaw using biocomposite materials.

The results of the analysis of the insulin-assortimet medicinal products on the pharmaceutical market of Uzbekistan. The results of this analysis will be used in future marketing research market insulin-containing medicines, with a view to identifying areas of domestic production and the creation of a system of rational use.

The phytologic and morphological characteristics of Perovskia type were studied. There are represented data of the plant supervision, growth and development of Perovskia scrophulariifolia under the condition of culture of the Botanical garden named after E.Gareev of National Academy of Sciences of the Kyrgyz Republic, Bishkek city.

The analysis of the states of medicinal providing of separate diseases is conducted at ambulatory level in the Kyrgyz Republic during 2006-2013years. The program of State guarantees working for seven years led to the following writing of recipes increased in 1,8 times, the volume of compensation sum from Fund of obligatory medical insurance grew in 2,3 times. There are problems of narcotic, psychotropic drugs accessibility in remote settlements.

Аntiinflammatory activity of the new combined ointment was studied with the equivalent on the by pharmacological action ointment «Wundahyl». It is established that the new combined ointment promoted the significant decrease of inflammation and intensity of defeat a skin. An anti-inflammatory action of ointment «Prolidoxid» was higher than the preparation of comparison ointments «Wundahyl» in 1.5 times. More expressed anti-inflammatory action of new ointment is caused by interaction of antioxidative and membranostabilizative activity of hydrophobic drug phenolic propolis operating, their high bioavailability due to the polyethylene oxide basis. Received results prove further study in order to apply the new combined ointment for local treatment of non allergic inflammatory diseases of a skin.

It is carried out the pharmacognostic description Perovskia abrotanoides Karel and it is determined microscopic characteristics.

The results of chemoprophylaxis of the echinococcosis recurrence in 114 patients are presented. Three courses of albendasole according to the scheme had been prescribed. Recurrence was in two patients (1,7%).

Dynamics of echinococcus disease increase in Kyrgyz Republic during last 12 year are done. It was noted it s constant growth.

The results of analysis of the efficacy of the usage of the modern methods of treatment in cholelithiasis in different stages of medical assistance to these patients were given. On the every stage of medical assistance to patients with cholelithiasis additional methods of investigation in dependence of equipment and human capacity are needed. The algorithm for the diagnosis cholelithiasis is the must. Developed algorithm for the preoperational diagnostics of the cholelithiasis is presented. In this algorithm we take into account the possibilities of the laboratory and instrumental methods usage.

The analysis of the hepatic echinococcosis treatment was performed in 12 patients after abdominisation of the fibrous capsule cavity.

Operation on resection of iliac part of small intestine with imposing transverse invagination with controlled ileostomy in patients suffering from acute surgical illness of small intestine has been develop and applied.

The results of surgical treatment of 37 middle and senile age people with relapsing choledocholithiasis are presented.
External drainage was fulfilled in 12 patients, and internal drainage with application of biliodigestive anastomosis was fulfilled
in 25 patients. Complications were in 5 patients. There were no lethal outcomes.

Analysis of 102 urgently operated patients are done/ The dynamics of inflammatory reaction indexes were observed The dependence between the complication frequency and the quantity of inflammatory reaction symptoms was determined

The article provides information about the 21st World Congress of International Physicians for the Prevention of Nuclear War (IPPNW) held in Astana in August 25-30, 2014 under the slogan “From a Nuclear Test Ban to a Nuclear Weapon Free World: Disarmament, Peace and Global Health in the 21st Century”

Асан Джайлобаевич Джайлобаев (к 80-летию со дня рождения)

ВТОРОЙ ЕЖЕГОДНЫЙ КОНКУРС «АКЫЛ ТИРЕК»

Шаршенов Асанбек Карыпбекович (1954-2012)