ПАТОГЕНЕЗ АПЛАСТИЧЕСКОЙ АНЕМИИ (ОБЗОР ЛИТЕРАТУРЫ)
DOI:
https://doi.org/10.54890/.v2i2.990Аннотация
Апластическая анемия является редкой и опасной для жизни недостаточностью костного мозга, которая приводит к цитопении периферической крови и снижению пролиферации гемопоэтических клеток костного мозга. Симптомы сходны с миелофиброзом, миелодиспластическими синдромами и острым миелоидным лейкозом, что затрудняет диагностику данного заболевания. Патогенез апластической анемии сложен, и его механизм необходимо расшифровывать на индивидуальной основе. В этом обзоре обобщаются несколько вкладов, сделанных в последние годы в попытке понять патогенез апластической анемии, которые могут быть полезны для разработки персонализированных методов лечения данного заболевания.
Ключевые слова:
апластическая анемия, определение, патогенез, гемопоэтические стволовые клетки, клетки-предшественники, иммунная дисфункция.Библиографические ссылки
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