DIAGNOSIS OF MILD TRAUMATIC BRAIN INJURY DETECTING S-100B PROTEIN LEVEL IN VICTIMS
DOI:
https://doi.org/10.54890/.v5i5.690Abstract
Objective: to determine the diagnostic value of protein S-100B level in blood serum at patients with mild head injury. M aterial and methods. We conducted prospective assessment of protein S100Blevel in blood serum at 19 patients, received conservative treatment because of mild head injury at Neurosurgical Clinic of National Hospital for the period of time 2012-2017. All patients underwent clinico-neurological examination, brain CT and brain MRI, electroencephalography (EEG). The level of protein S100B in blood serum was determined at onceduring patients’ admission, then repeated evaluation - in 24 and 48 hours. The comparative analysis of data, received by clinico-instrumental examination and measurement of protein S100Blevel at patients with mild head injury, was carried out. Results and discussion. We revealed the increase of protein S100B level higher than normal value (more than 105 tg/l) at 11 (58%) patients during first 6 hours after trauma. The elevation of protein S100Blevel in blood serum showed that there was structural damage of brain tissue (brain contusion). Brain CT revealed foci of brain injuries only at 73% of patients with increased protein S100B level (n=11 patients), while MRI - at 100%. Brain CT and MRI revealed no pathological areas in brain at patients with normal value of protein S-100e (n=8 patients).
There were no correlations between protein S100Blevel and type of brain injury, localization and volume of pathological focus and presence of cranial bones fractures. Also there was no significant correlation between protein S-100B level and changes in EEG (р > 0,05). Conclusions. Protein S100B is high-sensitivity biochemical marker of neural tissue damage. The elevation of protein S-100B level in blood serum at patients with mild head injury may be the additional criteria at determining the diagnosis of brain contusion.
Keywords:
mild head injury, biochemical markers, protein S100BReferences
1. Корниенко В.Н., Васин Н.Я., Кузьменко В.А. Компьютерная томография в диагностике черепно-мозговой травмы. - М.: Медицина, 1987. - C. 288.
2. Лебедев В.В., Крылов В.В. Неотложная нейрохирургия: Руководство для врачей. - М.: Медицина, 2000. - С. 568.
3. Лихтерман Л.Б., Потапов А.А. Классификация черепно-мозговой травмы / / В кн.: Клиническое руководство по черепно-мозговой травме. - М. «Антидор», 1998. - Том 1. - С. 47-128.
4. Мамытов М.М., Ырысов К.Б., Мамытова Э.М. Дифференцированный подход в лечении ушибов головного мозга // Вестник неврологии, психиатрии и нейрохирургии (Москва), 2014. - №12. - С. 43-48.
5. Мамытов М.М., Ырысов К.Б., Мамытова Э.М. Нейрохирургические проблемы очаговых поражений головного мозга. - Бишкек: Алтын тамга, 2010. - 190 с.
6. Мамытов М.М., Ырысов К.Б., Мамытова Э.М. Факторы дифференцированного подхода в лечении тяжелых очаговых повреждений головного мозга / / Лжарська справа, 2012. - №6. - С. 68-73.
7. Потапов А.А., Лихтерман Л.Б., Зельман В.Л. Доказательная нейротравматология. - М.: Анти- дор, 2003. - С. 517.
8. Ырысов К.Б., Азимбаев К.А., Ырысова М.Б. Магнитно-резонансная томография в диагностике нейроструктурных нарушений при тяжелой черепно-мозговой травме //Актуальные проблемы гуманитарных и естественных наук. - 2016.- №11-2. - С. 126-129.
9. Ырысов К.Б. Значение дополнительных методов исследования при черепно-мозговой травме // I Международная научно-практическая конференция «Актуальные вопросы медицины». - Баку, Азербайджан. 30-31 марта 2012. - С. 69.
10. Akhtar J.I., Spear R.M., Senac M.O. Detection of traumatic brain injury with magnetic resonance im aging and S-100B protein in children, despite normal computed tomography o f the brain // Pediatr. Crit. Care Med. - 2003. - Vol. 4 (3). - P. 322-326.
11. Biberthaler P., Mussack T., Wiedemann E. Evalua tion o f S-100B as a specific marker for neuronal damage due to minor head trauma // World J. Surg. - 2001. - Vol. 25 (1). - P. 93-97.
12. de Boussard C.N., Lundin A, Karlstedt D. S100 and cognitive impairment after mild traumatic brain in jury // J. Rehabil. Med. - 2005. - Vol. 37. - P. 53-57.
13. Hermann M., Jost S., Kutz S. Temporal profile of release o f neurobiochemical markers o f brain damage after traumatic brain injury is associated with intra cranial pathology as demonstrated in cranial computerized tomography // J. Neurotrauma. - 2000. - Vol. 17 (2). - P. 113-122.
14. Ingebrigtsen T., Romner B., Marup-Jensen S. The clinical value o fserum S-100 protein measurements in mi nor head injury: a Scandinavian multicentre study // Brain Inj. - 2000. - Vol. 14 (12). - P. 1047-1055.
15. Korfias S., Stranjalis G., Papadimitriou A. Serum S-100B protein as a biochemical marker o f brain in jury: a review o f current concepts // Curr. Med. Chem. - 2006. - Vol. 13 (30). - P. 3719-3731.
16. Moore B.W. A soluble protein characteristic of the nervous system // Biochem. Biophys. Res. Comm. 1965. - Vol. 19. - P. 739-744.
17. Muller K, Townend W, Biasca N. S100B serum level predicts computed tomographyfindings after minor head in jury//! Trauma. - 2007. - Vol. 62 (6). - P. 1452-1452.
18. Romner B., Ingebrigtsen T., Borgesen S.E. Traumatic brain damage: serum S-100 protein measure ments related to neuroradiologicalfindings // J. Neurotrauma. - 2000. - Vol. 17 (8). - P. 641-647.
19. Sedaghat F., Notopoulos A. S100 protein family and its application in clinical practice // Hippokratia.- 2008. - Vol. 12 (4). - P. 198-204.
20. Stranjalis G., Korfias S., Papadimitriou A. Elevated serum S-100B protein as a predictor o f failure to short-term return to work or activities after mild head injury // J. Neurotrauma. - 2004. - Vol. 21 (8).- P. 1070-1075.
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