THE EFFECT OF L-ARGININE ON HIGH MOUNTAINS DISADAPTATIONS
Abstract
Resume. The Goal - to conduct a comparative study of the influence of L-arginine on the manifestation of alpine adaptation at an altitude of 4100 meters above sea level in the base camp North Inylchek (Eastern Tien Shan).Materials and methods. Based on the Lake Louise scoring system, 28 people in case of high mountains disadaptation were assessed oxygen saturation, blood pressure and pulse response during 24 hours of adaptation at an altitude of 4,100 m. The main group of 16 people took aspartate L-arginine in the form of oral solution (Tivortin preparation, Yuri-Farm production, Ukraine) in a dose of 1 gram (5 ml) up to 8 times a
day. The control group was the other 12 people who did not take Tivortin.
Results: Compared to the control group, the main group of those who took L-arginine aspartate showed a faster cessation of symptoms of high mountains disadaptation and increasing of SpO2. At the same time, they have seen favorable shifts in hemodynamic parameters - lower blood pressure and lower heart rate. Tivortin was well tolerated by those who were examined.
Conclusion: Aspartate L-arginine in the form of oral solution (Tivortin) can be recommended to optimize adaptation to high mountains. It is advisable to study the effectiveness of aspartate L-arginine in acute mountain disease of varying severity.
Keywords:
high-altitude adaptation, high mountains disadaptation, L-arginine, TivortinReferences
1. Миррахимов М.М., Гольдберг П.Н. Горная медицина. - Фрунзе: Издательство «Кыргызстан», 1978. - 184 с.
2. Бримкулов Н.Н., Хамзамулин Р.О. Острая горная болезнь //Здравоохранение Кыргызстана. 1994. - №3-4. - С. 21-30.
3. АкуновА.Ч., СарыбаевА.Ш. Острая горная болезнь и новое в её патофизиологии // Наука и новые технологии. - 2010.- №1. - С. 119-121.
4. Li Y., Zhang Y., Zhang Y. Research advances in pathogenesis and prophylactic measures o f acute high altitude illness. Respiratory Medicine 2018. 145:145 152, DOI:https://doi.org/10.1016/j. rmed.2018.11.004
5. JacksonA.I.R., Cumpstey A.F., Grocott M.P.W. Acute high-altitude pathologies and their treatment. Current Opinion in Endocrine and Metabolic Research 2020, 11:42-48.
6. Beall C.M., Laskowski D., Erzurum S.C. Nitric oxide in adaptation to altitude. FreeRadicBiolMed. 2012. 52(7): 1123-1134. doi: 10.1016/j.freeradbiomed.2011.12.028
7. Schneider J-C., Blazy I., Dechaux M., Rabier D., Mason N.P., Richalet J-P. Response o f nitric oxide pathway to l-arginine infusion at the altitude o f4,350 m. European Respiratory Journal 2001. 18(2):286 292.
8. Mansoor J. K., Morrissey B. M., Walby W. F., Yoneda K. Y., Juarez M., Kajekar R., Schelegle E.S. L-arginine supplementation enhances exhaled NO, breath condensate VEGF, and headache at 4342 m. High Altitude Medicine and Biology 2005. 6(4):289-300. https://doi.org/10.1089/ham.2005.6.289
9. Roach RC., Bartsch P., Hackett PH., Oelz O. The Lake Louise Acute Mountain Sickness Scoring System // Hypoxia and Molecular Medicine. - 1993. - P. 272-274.
10. Roach RC., Hackett PH, Oelz O., Bartsch P., Luks AM., Maclnnis MJ. The 2018 Lake Louise acute mountain sickness score // High Alt Med Biol. - 2018. - № 19(1). P 4-6.
11. Гунина Л. М., Винничук Ю. Д., Дмитриев А. В., Высочина Н. Л., Безуглая В.В., Носач Е. В. Тивортин аспартат: новый безопасный и эффективный фармакологический препарат для стимуляции работоспособности спортсменов. Украгнський журнал медицини, бюлогп та спорту. - 2017. - № 3 (5). - С. 229-244. DOI: 10.26693/jmbs02.03.229
12. Лутай Ю.А., Крючкова О.Н., Ицкова А.А., Лебедь Е.И. Эффективность препарата Тивортин в лечении пациентов со стабильной стенокардией напряжения // Кримський терапевтичний журнал - 2013. - №1. - С. 65-69.
13. Жаринова В.Ю., Бутинец Ж.С., Павленко Л.А. Эффективность применения L-аргинина в лечении хронической сердечной недостаточности у больных с ишемической болезнью сердца пожилого возраста // Семейная медицина. - 2014. - №5 (55). - С. 34-38.
14. Siques P, Brito J, Schwedhelm E, Pena E, Leon-Velarde F, De La Cruz JJ, Boger RH and Hannemann J. Asymmetric Dimethylarginine at sea level is a predictive marker of Hypoxic Pulmonary Arterial Hypertension at High Altitude. Front. Physiol. 2019. - 10:651. doi: 10.3389/ fphys.2019.00651
