ASSOCIATION OF TRP64АARG POLYMORPHISM OF В3 ADRENOCEPTORS WITH LIPID PROFILE IN GROUP OF ETHNIC KYRGYZES
Abstract
in group of ethnic Kyrgyz the Arg64 allele of ADRB3 gene was associated with decreased HDL-cholesterol.
Keywords:
β–adrenoceptors, Trp64Arg polymorphism, lipid profile, atherogenic dyslipidemia.References
1. Bouchard C., Trembly A., Despres J.P., et al. The response to long-term overfeeding in identical twins. N Eng J Med. 1990; 322: 1477-1482.
2. Carmelli D., Cardon L.R., Fabsitz R. Clustering of hypertension, diabetes, and obesity in adult male twins: same genes or same environments. Am J Hum Genet 1994; 55:566-573.
3. Strosberg A.D. Association of β3-adrenoceptor polymorphism with obesity and diabetes: current status. Trends Pharmac Sci 1997; 18:449-45
4. Ursino M.G., Vasina V., Raschi E., et al. The b 3-adrenoceptor as a therapeutic target: current perspectives // Pharmacol Res. – 2009. – Vol. 59. – P.221–234.
5. Krief S., Strosberg A.D., Nyberg S., et al. Tissue distribution of В3-adrenergic receptor mRNA in man // J. Clin. Invest. - 1993. – Vol. 91. - P.344-349.
6. Lönnqvist F., Krief S., Strsberg A.D., et al. A pathogenic role of visceral fat b3-adrenoceptors in obesity // J. Clin. Invest. - 1995. - Vol. 95. - P.1109–1116.
7. Susulic V.S., Frederich R.C., Lawitts J., et al. Targeted disruption of the β3-adrenergic receptor gene. J Biol Chem 1995;270: 29483-29492.
8. Widen E., Lehto M., Kanninen T., et al. Association of a polymorphism in the β3-adrenergic receptor gene with features of the insulin resistance syndrome in Finns // N. Engl. J. Med. - 1995. - Vol. 333. - P.348-351.
9. Walston J., Silver K., Bogardus C., et al. Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the b3-adrenergic-receptor-gene // N. Engl. J. Med. - 1995. - Vol. 333. - P.343–7.
10. Clement K., Vaisse C., Manning B., et al. Genetic variation in the b3-adrenergic-receptor and an increased capacity to gain weight in patients with morbid obesity. N Engl J Med 1995; 333:352-4.
11. Fujisawa T., Ikegami H., Yamato E. et al. Association of Trp64Arg mutation of the b3-adrenergic-receptor with type 2 diabetes and body weight gain // Diabetologia.-1996.- Vol.39. - P349-52.
12. Yoshida T., Sakane N., Umekawa T., et al. Mutation of b3-adrenergic-receptor gene and response to treatment of obesity. Lancet 1995; 346: 1433-1434.
13. Santos J.L., Perez-Bravo F., Martinez J.A., et al. No evidence for an association between genetic polymorphisms of beta(2)- and beta(3)-adrenergic-receptor genes with body mass index in Aymara natives from Chile. Nutrition 2002;18:255-258.
14.Hsueh W., Cole S., Shuldiner A., et al. Interactions between variants in the b3-adrenergic-receptor and peroxisome proliferator-activated receptor-y2 genes and obesity. Diabetes Care 2001; 24: 672-677.
15. Xinli W., Xiaomei T., Meihua P., Song L. Association of a mutation in the beta 3-adrenergic-receptor gene with obesity and response to dietary intervention in Chinese children. Acta Paediatr 2001;90: 1233-1237.
16. Ghosh S., Langefeld C.D., Ally D., et al. The W64R variant of the β3-adrenergic receptor is not associated with type II diabetes or obesity in a large Finnish sample. Diabetologia 1999; 42: 238-244.
17. Friedewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge // Clin. Chem. - 1972. - Vol. 18. - P.499-502.
18. Tonolo G., Melis M.G., Secchi G., et al. Association of Trp64Arg в3-Adrenergic-receptor gene polymorphism with essential hypertension in the Sardinian population // J. Hypertens. - 1999. - Vol. 17. - P.33-38.
19. Kadowaki H., Yasuda K., Iwamoto K., et al. A mutation in the b3-adrenergic receptor gene is associated with obesity and hyperinsulinemia in Japanese subjects // Biochem. Biophys. Res. Commun. - 1995. - Vol. 215. - P.555–560.
20.Hao K., Peng S., Xing H., et al. b3-Adrenergic receptor polymorphism and obesity-related phenotypes in hypertensive patients // Obesity. Res. - 2004. - Vol. 12. - P.1433–1434.
21. Oksanen L., Mustajoki P., Kaprio J., et al. Polymorphism of the beta 3-adrenergic receptor gene in morbid obesity // Int. J. Obes. Relat. Metab. Disord.- 1996.- Vol. 20.-P.1055-61.
