FIBRINOGEN CONCENTRATION AT THE STAGES OF DISTRACTION OSTEOSYNTHESIS OF ILIZAROV DURING SHORT-TERM ADAPTATION TO HIGH-ALTITUDE CONDITIONS IN THE EXPERIMENT
DOI:
https://doi.org/10.54890/1694-8882-2024-4-%2036Abstract
Among the body systems, a hemostasis system that provides liquid state of the blood is one of the most labile systems. This is the reason for any effects on the body both external and internal factors resulted to the disorders in the dynamic balance status between the coagulation and fibrinolytic components of the hemostatic system. It makes this issue study very important. Moreover, an urgency of this issue study is deeper by the fact that the mountain landscape in the Kyrgyz Republic is about 90%. Approximately 20% of the population lives in mountain areas, and 30% lives in the foothills. All the studies we have conducted in the conditions of high mountains based on Tuya-Ashuu at the altitude of 3.200 meters above the sea level. In addition, the issues of providing the musculoskeletal system with oxygen, the direct manifestation of this system, are largely determined by the functional state of the hemostasis system, therefore, the study of structural and functional changes in the bone tissue of the body, adapting to high altitude conditions, and the process of bone generation in the body. in the mountains when they are damaged are of great importance. In parallel, the hemostasis system, of course, affects not only the functional state, but also the regenerative capabilities of tissues and organs. In this case, regeneration of skeletal bones is, on the one hand, not only one of the most important sections of modern traumatology but also, on the other hand, an integral part of a single general biological process of restructuring
Keywords:
osteotomy, distraction, hemostasis, fibrinolysis, coagulation, high mountains, hyperfibrinogenemia, experiment, thromboembolism.References
1. Садабаев Э.М., Тажибаева У.Ж., Арстанбекова М.А., Нартаева А.К., Иманалиева Ф.Э., Маматов С.М. Патогенез апластической анемии. Вестник Кыргызской государственной медицинской академии им. И.К Ахунбаева. 2023;2:56-64. [Sadabaev E.M., Tazhibaeva U.Zh., Arstanbekova M.A., Nartaeva A.K., Imanalieva F.E., Mamatov S.M. Pathogenesis of aplastic anemia. Bulletin of the Kyrgyz State Medical Academy. 2023; 2: 56-64. (In Russ.)]. https://doi.org/10.54890/1694-6405_2023_ 2_56
2. Журкабаева Б.Д., Аскарова А.Е. Состояние системы гемостаза и фибринолиза при геморрагическом инсульте у детей грудного возраста. Медицина (Алматы). 2018;12:18-21. [Zhurkabayeva B.D., Askarova A.E. The state of the hemostasis and fibrinolysis system in hemorrhagic stroke in infants. Medicine (Almaty). 2018; 12: 18-21. (In Russ.)]. https://doi.org/10.31082/1728-452X-2018-198-12-19-21
3. Шлыков И.Л., Кузнецова Н.Л., Трифонова Е.Б, Антропова И.П., Вараксин А.Н. Гемостазиологическая оценка степени тяжести состояния пациента с травмой таза. Политравма. 2012;1:54-58. [Shlykov I.L. Kuznetsova N.L., Trifonova E.B. I. Antropova.P., Varaksin A.N. Hemostasiological assessment of the severity of the patient's condition with a pelvic injury. Polytrauma. 2012;1:54-58 (In Russ.)].
4. Жуков А.И., Клычникова Е.В., Бадыгов С.А., Заднепровский Н.Н., Богданова А.С., Кочетова А.А. и др. Посттравматическая коагулопатия у пострадавших с политравмой. Политравма. 2024;1:12-19. [Zhukov A.I.,Klychnikova E.V., Badygov S.A., Zadneprovsky N.N., Bogdanova A.S., Kochetova A.A., et al. Posttraumatic coagulopathy in polytrauma victims Polytrauma. 2024;1:12-19 (In Russ.)].
5. Акылбеков Р.К., Кулматов Т.Н. Климатические и рекреационные ресурсы как условия для лечения, профилактики здоровья и отдыха населения. Вестник Кыргызского национального университета имени Жусупа Баласагына. 2022;3:239-245. [Akylbekov R.K., Kulmatov T.N. Climatic and recreational resources as conditions for the treatment, prevention of public health and recreation. Bulletin of the Zhusup Balasagyn Kyrgyz National University. 2022;3:239-245. (In Russ.)]
6. Овчинников Е.Н., Филимонова Г.Н., Дюрягина О.В., Тушина Н.В., Киреева Е.А. Влияние различных режимов электровоздействия на скелетные мышцы удлиняемого сегмента при дистракции голени по Илизарову. Казанский медицинский журнал. 2024;1:73-83. [Ovchinnikov E.N., Filimonova G.N., Dyuryagina O.V., Tushina N.V., Kireeva E.A. The effect of various modes of electrical action on the skeletal muscles of the elongated segment during the distraction of the shin according to Ilizarov. Kazan Medical Journal. 2024; 1: 73-83. (In Russ.)] https://doi.org/10.17816/KMJ465709
7. Багиров А.Б., Лаймуна К.А., Шестерня Н.А., Алинагиев Б.Д., Суварлы П.Н. Эффективность модифицированных компановок аппаратов наружной фиксации при устранении варусной деформации голеней. Политравма. 2021;2:50-59. [Bagirov A.B., Laimuna K.A., Gear N.A., Alinagiev B.D., Suvarly P.N. The effectiveness of modified lines of external fixation devices in eliminating varus deformation of the shins. Polytrauma. 2021;2:50-59 (In Russ.)].
8. Шуваева В.Н., Горшкова О.П., Дворецкий Д.П. Коагуляционный гемостаз у крыс линии вистар после кратковременной транзиторной ишемии головногомозга. Российский физиологический журнал им. И.М. Сеченова. 2019;9:1189-1196. [Shuvaeva V.N., Gorshkova O.P., Dvoretsky D.P. Coagulation hemostasis in wistar rats after short-term transient cerebral ischemia. I.M. Sechenov Russian Journal of Physiology. 2019;9:1189-1196. (In Russ.)]. https://doi.org/10. 1134/ S0869813919090127
9. Шойбонов Б.Б., Драпкина О.М., Баронец Т.П., Серебрякова Н.Ю., Худяков М.Б. Простой способ определения фибриногена и оценка его функциональности. Патогенез. 2020;1:74-81. [Shoibonov B.B., Drapkina O.M., Baronets T.P., Serebryakova N.Yu., Khudyakov M.B. A simple way to determine fibrinogen and evaluate its functionality. Pathogenesis. 2020;1:74-81. (In Russ.)]. https://doi.org/10.25557/2310-0435.2020.01.74-81
10. Нечипуренко Д.Ю., Пантелеев М.А., Синауридзе Е.И., Троянова К.С. Механизмы регуляции свертывания крови: история исследований и перспективы. Биофизика. 2023;1:66-78. [Nechipurenko D.Yu., Panteleev M.A., Sinauridze E.I., Troyanova K.S. Mechanisms of blood coagulation regulation: research history and prospects. Biophysics. 2023;1:66-78 (In Russ.)]. https://doi.org/10.31857/S0006302923010076
Downloads
Published
How to Cite
Issue
Section
