Vol. 2 No. 2 (2014): VESTNIK of KSMA

The article presents data studies of antitumor properties of pectin in the model of transplanted tumors in rats. Screening of antitumor activity of pectin was conducted on three transplantable rat tumors: spindle cell sarcoma 45, Walker carcinosarcoma 256, Pliss lymphosarcoma. The data obtained in the experiment demonstrated antitumor properties of pectin, since it satisfies the one criteria of selection of the explored drugs.

The results of the investigation vagus nerves topography are representing in the article. In dissection of the thoracic organs atypical location of the thoracic right and left vagus nerves and its syntopy was describes in given paper.

The aim of the investigation was to define the sensitive periods of school children’s physical abilities who live in mountainous condition, development.

On the visual data based characterizing the wound process in experimental studies investigated the effectiveness of  local action tunma-cumys (low-alcoholic drink, milk of horses) for a first phase of wound healing. Proven The effectiveness of cumis using in the treatment of local wound healing process in comparison with other treatments was proven.

The results of the exploration of the students of Kyrgyz State Medical Academy lifestyle were discussed in the research and the prognosis was given. The prevalence of the risk factors, which influence on the healthy lifestyle was studied. These risk- factors were: insufficient physical activity, violation of regime of working and rest, regime of the food intake and it’s quality, smoking, light drugs use and alcohol consumption.

The article contains the results of the research of teenage young men 10-17 years living in low and middle mountains of Kyrgyz Republic. Somatometry was made, the physical growth’s level characteristics were given, the functional state of the cardiovascular system and initial autonomic nervous system tone of teenage young men was investigated.

The modern data concerning research of oncologic patients’ quality of life with the help of the international questionnaire of EORTC QLQ-C30 are submitted in this work. According to international standards language and cultural adaptation of EORTC QLQ-C30 questionnaire was made with taking into account ethno-linguistic features of population, tool validation and the Kazakh lingual version of a questionnaire EORTC QLQ-C30 equivalent to the original was created. The created version is characterized by high psychometric properties.

Research is devoted to the retrospective analysis of results of monitoring plague in the Sarydjas autonomous center for the aim of identification of priority sites for carrying out planned improving preventive actions for reducing its infectiousness. Material, containing the data of the epizootic survey of the different plague sites, collected over time was used for the analysis in this paper. Also the data of various methods of the territory sanation were given.

The analysis of cancer service condition in Kazakhstan using component analysis was made. Some problems of cancer patients’ registry and accounting in Kazakhstan were discussed. The importance of the absolute number of cancer patients and reasons for its the undercount in Kazakhstan were underlined in given paper. The expected number of cancer patients on the basis of primary statistics of cancer patients incidence during the 1999-2010 years was defined. It is established that the raising in cancer incidence associated with increasing of population and changing its age structure.

Determining the direction and degree of correlation between the complexes of factors and the prevalence of myopia among schoolchildren allows us to construct a hierarchical ladder of influence factors and their combinations. It gives the possibility to reveal the main chain of the factors and hence, it helps to develop and implement targeted interventions to mitigate or eliminate the negative factors on the efficiency trait. Analysis results can be used in pre-hospital stage screening diagnostics. Ophthalmologists receive not only additional information that improves the quality of the diagnostic process, but also the ability to optimize preventive work on the protection of school students.

To study an association between T455C apolipoprotein C-III (apo C3) gene polymorphism, insulin resistance (IR) and metabolic syndrome (MS) and its components in a Kyrgyz ethnic group.

32 patients’s with cholelithiasis and disturbance in bile outflow investigation results are presented in given paper. The efficacy of endoscopic papillosphincterectomy (EPST) in cholelithiasis and disturbance in bile outflow was 86.4%. The usage of EPST permitted to correct the disturbance of bile outflow and cholelithiasis, which were found in bile ducts investigation. Methods of intraoperational choledochoscopy, retrograde lithoextraction in cholelithiasis also were effective.

Any surgical treatment is leading to the protein catabolism. All patients in post-operative period are demonstrating the severe stage of the protein catabolism.

This paper presents an analysis of the results of radical and palliative treatment of 30 patients with tumors of biliary pancreatoduodenal zone, complicated with obstructive jaundice. The necessity of performing pancreatoduodenectomy as the only possible method is shown in the radical treatment of tumors periampular zone. The options of the bile flow in palliative surgery and postoperative complications are discussed.

Diagnostics and treatment of pancreas cystic formations is currently one of the most significant problems in surgery of the pancreas. Minimally invasive treatments for cystic formations of the pancreas are less traumatic and permit to reduce the length of stay in hospital and make the period of rehabilitation shortened, which is especially important for those young working patients.

Cerebrovascular pathology is one of the major causes of death rate and the leading cause of disability of population in the whole world. Search of new targets for nosotropic treatment of the initial stages of cerebrovascular insufficiency is especially actual. Regulation of apoptosis can have a positive influence on the processes of adaptation to the effects of vascular risk factors. Influence on the function of endothelia is perspective from the point of view of prevention and deceleration of progress of vascular defeat on the earliest stages of process. The aim of our research was clinical accounts score influence of L-arginine (Tivortin) on the vasomotor endothelium function and apoptosis in patients with early stages of cerebrovascular diseases.

The article presents the etiologic and clinical features of feet mycoses and onychomycosis in patients with diabetes type 2.

There is high burden of tuberculosis in Kyrgyzstan. The prevalence of extra pulmonary tuberculosis in the period 2002-2012 is 40% to 28,7%. The prevalence of central nervous system TB in the country is also raising during this period and estimates 1,1% to 2,5%. Mortality from this severe form of TB is very high. It is 51,1% among patients of the observed group – more than½ of all cases. The main risk factors of fatal outcome are drug resistance of MBT, HIV-positive status of patients and the late diagnosis of disease.

This article presents the analyzes of clinical study the various methods of urinary diversion, which are the bladder catheterization, suprapubic bladder puncture, trocar cystostomy, The main characteristics of the medical assistance are reflected in given paper, as well as a new method for suprapubic urinary diversion puncture under ultrasound guidance.

The results of the diagnostics and treatment of the 73 patients with the bleeding from esophageal veins in cirrhosis were analyzed. The efficiency of using the zund-obturator “Sengstakin-Blackmore” for the hemostasis in 66 patients in the first 24 hours of admission was demonstrated. In the absence of the effectiveness of the sclerotherapy and conservative treatment the choice of treatments was operation by Pacio in 13 patients. Rebleeding after the operation was observed in 2 patients and it stopped with the conservative methods of treatment. From renal and hepatic failure 3 patients were died 3 in the «C» – severity level by Childe Turkot. The best results were received in the complex therapy with the using of the zund-obturator and sclerotherapy using and in timely using of relieving operations.

It is studied the fixation and stabilization of subperiostal implants in marked atrophy of alveolar processes of jaws.

In the given article the comparative analysis of investigation results of stability connection of metal adhesive prostheses and adhesive fibre glass prostheses with tooth hard tissue by experimental way is demonstrated.

The article presents of salivary glands diseases incidence in population of Kyrgyz Republic according to medical institutions data survey.

The results of assessment of general and gynecological health of 78 women in postmenopausal period, living in the social service institution in the were presented. They are characterized by polymorbidity – combination of 3 – 6 diseases, high level of cardiovascular pathology, chronic diseases of the gastrointestinal tract, endocrine pathology and pathological changes in the estrogen – dependent organs.

The case of delivery with imminent abortion, retrochorial hematoma with placenta previa complicated by sepsis was described in given article.

According to the results of analysis of pharmacoepidemiological the peculiarities of drug therapy in the treatment of hypertension on an outpatient service were defined. The list of the most commonly prescribed drugs in arterial hypertension (Bisoprolol, Amlodipine, Spironolactone, Ramipril, Perindopril, Lisinopril, Nebivalol, Losartan, Valsartan, Enalopril) was completed. Bisoprolol, from the group of β-blocker was highlighted as the dominant and prevalent drug, which was prescribed in pharmacoeconomical analysis.

It is actual to study and reveal new perspective resource kinds of essential volatile oil medicinal herbs which grow in Kyrgyzstan.

The results of investigation research of release speed of active ingredients from the children’s “Ibuprofen-S” pills on advanced structure by in vitro method are given in this paper. There are also results of some factors influence on the speed of release of active agent such as supplement substances, volume and рН the dissolving environment, the speed of a basket rotation.

Pills production, except in rare cases, is always accompanied by the addition of the supplements. A variety of brands of the supplementary substances on the market creates a need to study their impact on the technology of the solid dosage forms. This study investigates the effect of the glidants on the technological properties of the pills mass to select the more promising tools for the pharmaceutical industry. Aerosil and Neusilin were selected as the objects of the clinical trial. Their adsorption capacity, their influence on the slope angle, swing weight of the tablets were studied by the adding the objects of the study.

The number of syntheses of 2,4-substituted quinazolines was performed and its biological activity was investigated. Results of researches demonsrtaed that investigated 2-H (methylthio) quinazoline-4-ilydeneacetic ethers have grows regulating and fungicide activity.

The results of studying of some physical, chemical and technological properties of active substances and supplements are given in this paper. The substances were studied with the aim of forecasting of a choice of structure and technology of anti-inflammatory action pills «Ibuasktamol». As a result of the conducted research the main criteria of approach to development of structure and technology of the pills «Ibuasktamol» were defined.

The state of training, retraining, improvement of personal qualification for pharmaceutical branch, organization of work and production of domestic pharmaceutical manufacturers, ensuring their personnel and skills necessary for the organization of modern enterprises were explored. The regulations of training of the specialists were analyzed and compared with the actual requirements of the modern pharmaceutical market. According to results of the research the organization courses for improvement qualification and training personnel for drug manufacturers has been proposed.