TO THE QUESTION OF WORKING OUT THE DISSOLVING” TEST FOR CAPSULES OF NON- STEROIDAL ANTI – INFLAMMATORY ACTION

Abstract

One of the main quality indicators of modern medicinal preparations are biopharmaceutical indicators, i.e. “Dissolving” the test - for solid dosage forms. In this article are given the results of researches on working out the “Dissolving” test for enteric soluble capsules of Diclofenac sodium and paracetamol which have been elaborated in the Tashkent Pharmaceutical Institute. On the results of the conducted researches have been chosen the following conditions of determination the bioavailability of the analyzed capsules by the in vitro method: for determination the dissolving profile are used two dissolving mediums – 0,1 M of hydrochloric acid solution (capsules must not be dissolved during 60 min) and phosphate buffer solution with pH 7,4 (du-ring 45 min must be isolated no more than 75 % of active substances), medium volume – 1000 ml, punnet speed rotation – 100 v/min, temperature – 37±10С.