RESULTS OF INVESTIGATION OF LEVELS OF KEY MOLECULES OF FIBROGENESIS IN CHRONIC HDV-INFECTION
DOI:
https://doi.org/10.54890/.v6i6.700Abstract
Summary. Viral hepatitis D is considered the most severe form of viral hepatitis. Only 25% of patients respond to therapy. Chronic HDV infection leads to a more severe liver disease than chronic HBV-monoinfection and is associated with rapid development of fibrosis and an increased risk of hepatocellular carcinoma, as well as early decompensation of an already existing liver cirrhosis.
105 patients with chronic viral hepatitis delta were examined. All subjects underwent IL-12 levels, tumor necrosis factor alpha, IL-17, IL-10, transforming growth factor beta-1 in serum by ELISA (IBL (Germany)).
The results of the level study showed a significant increase in TNF-alpha, interleukin-10, depending on the stage of fibrosis. Levels of IL17, IL12 / 23, and TGFβ1 were elevated in patients with F3-F4 fibrosis in comparison with patients with fibrous stage F0-F2. Positive statistically significant association of the level of TNF-α and the level of intreleukin-10 with the fibrosis stage, with the level of ALT, AST and negative with values of creatinine, urea, platelets and leukocytes was found.
Keywords:
hepatitis delta, liver cirrhosis, cytokines, TNF-alpha, interleukin-10, interleukin17, TGFβ1.References
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