RESULTS OF COMBINED USE OF RADIO-CHEMOTHERAPY COMPONENT AMONG PATIENTS WITH CERVICAL CANCER

DOI:

https://doi.org/10.54890/.v1i1.583

Abstract

The main treatment for cervical cancer are surgery and radiation, the role of chemotherapy in this localization is not well studied. Chemotherapy is also used among patients with metastases in the pelvic and paraaortic lymph nodes with little chance of recovery by conventional methods. Moreover, anticancer drugs could be used as a modifier in combination with radiotherapy. Concurrent radiotherapy regimens are now becoming standard in the treatment of locally advanced process. During our research, among 58 patients with locally advanced cervical cancer, as a radio-modifier we used cisplatin 40 mg / m2 intravenously with hydration once a week during radiotherapy. Objective response was 77.6%.

Keywords:

cervical cancer, cisplatin, radiomodification, radiotherapy

References

1. Ермакова И.А. Роль химиотерапии на различных этапах лечения рака шейки матки // Практ. онкология. -2002.-№3.- С211-219.

2. ИванковаВ.С., Хруленко Т.В., Курило Г.Е. и др. Применение фторафура как радиомодификатора при лучевой терапии больных раком шейки матки // Лучевая диагностика, лучевая терапия. - 2007. - №3. -С.61-65.

3. Столярова И.В., Винокуров В.Л., Жаринов Г.М. и др. Результаты полирадиомодификации при лучевой терапии рака шейки матки и тела матки // Мед. радиол. -1992.-№3-4.-С.27-31.

4. Ульяненко С.Е., Политюкова Н.А. Радиомодифицирующий эффект гипрегликемии, зависимость от дозы глюкозы и объема опухоли // Мед. радиол.-1991-№1.-С.21-23.

5. Демидова Л.В., Телеус Т.А., Новикова Е.Г. Опыт лучевой терапии больных раком шейки матки в МНИОИ им.П.А.Герцена (1978-1998) // Тез. докл. пленума правления Всерос.науч.мед.общества онкологов «Высокие медицинские технологии в лучевой терапии злокачественных опухолей». - Ростов н/Д, 1999.-С.48-50.

6. Rose P.G., Bundy B.N., Watkins E.B. et al. Concurrent cisplatin based radiotherapy and chemotherapy for locally advanced cervical cancer // N. Engl.J.Med.-1999.-Vol.340.-P.1144-1153.

7. Keys H.M., Bundy B.N., Stehman F.B. Cisplatin, radiation and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage Ib cervical carcinoma //N. Engl. J. Med.-1999.- Vol.340.-P.1154-1161.

8. Morris M., EifelP., Lu J. Pelvic radiation with concurrent chemotherapy compared with pelvic and paraaortic radiation for high risk cervical cancer // N. Eng. J. Med. -1999.-Vol.340.-P.1137-1143.

9. Peters W., Liu P., Barret R. Cisplatin, 5-fluorouracil plus radiation therapy are superior to radiation therapy as adjuctive therapy in high-risk, early-stage carcinoma o f the cervix after radical hysterectomy and pelvic lymphadenectomy // Gyn. Oncol/-1999/- №8484.-P. 797.

Published

2023-04-06

How to Cite

Абдылдаев, Т., С. . Найзабекова, and Ж. . Балтабаева. “RESULTS OF COMBINED USE OF RADIO-CHEMOTHERAPY COMPONENT AMONG PATIENTS WITH CERVICAL CANCER”. Euroasian Health Journal, vol. 1, no. 1, Apr. 2023, pp. 143-6, doi:10.54890/.v1i1.583.

Issue

Section

OBSTETRICS AND GYNECOLOGY