EVALUATION CHANGES IN INDICATORS OF ONCOLOGICAL SERVICE IN LIVER CANCER IN KAZAKHSTAN

Abstract

According to the International Agency for Research on Cancer, about 906 thousand new cases of liver cancer (LC) are registered annually in the world and in 2040 about 1.4 million are predicted and about 1.3 million are expected to die from this pathology.
Aim of the study: to evaluate some indicators of the oncological service for RP in Kazakhstan for 2010-2019.
The research material was the data of the Ministry of Health of the Republic of Kazakhstan  - annual form 35, concerning RP (ICD 10-C22) for 2010-2019 - morbidity, mortality, early diagnosis, neglect, morphological verification. A retrospective study using descriptive and analytical methods of biomedical statistics was used as the main method.
For 2010-2019 For the first time, 8,335 new cases of LC and 6,037 deaths from this pathology were registered in the republic. The average annual rough indicator of the incidence of LC was 4.8±0.10/0000 (95% CI=4.6-5.0) and in dynamics had a not pronounced tendency to increase from 4.9±0.20/0000 in 2010 to 5.0±0.20/0000 in 2019, the difference was statistically insignificant (p> 0.05). In dynamics, mortality rates from RP tended to bestatistically significant (t=7.95 and p=0.000) decrease from 4.8±0.20/0000 in 2010 to 3.5±0.10/0000 in 2019, and the average annual gross mortality rate from LC was 3.9±0.20/0000 (95% CI=3.5-4.2). Indicators of early diagnosis (the proportion of patients with stages I-II) improved from 8.7% in 2010 to 19.3% in 2019, while the proportion of patients with stage IV decreased (from 31.8% to 17.2 %), and the proportion of patients with stage III increased (from 59.5% to 63.3%) over the years studied, i.e. neglect rates are generally declining. Indicators of morphological verification in LC over the years under study tended to improve
from 38.3% to 64.2%.
As a result of the analysis of the indicators of the oncological service in LC, an improvement in the indicators of morphological verification and early diagnosis, a decrease in the neglect of the process and mortality rates were established, which is undoubtedly associated with the ongoing anti-cancer measures in Kazakhstan.