ПОЛИМОРФИЗМ FOKI, TAQI, BSMI, APAI И CDX2 РЕЦЕПТОРА  ВИТАМИНА Д (VDR) С ВОСПРИИМЧИВОСТЬЮ  К ТУБЕРКУЛЕЗУ ЛЕГКИХ: СРАВНИТЕЛЬНЫЙ АНАЛИЗ

A. Akhmetova

doi:10.54890/.v4i4.347

A. Akhmetova

DOI:

https://doi.org/10.54890/.v4i4.347

Abstract

Abstract. The main goal of the study was to determine the frequency of ApaI, TaqI, FokI, BsmI and Cdx2 in the Kazakh population. The purpose of this study is to identify the association of nucleotide substitutions in the VDR gene with a predisposition to pulmonary tuberculosis for the population of Kazakhstan. As a material for research, collections of DNA samples isolated from the peripheral blood of patients with pulmonary tuberculosis and healthy individuals of primary blood-grooming were used. Statistical processing was carried out using the χ2 criterion. Vitamin D modulates the activity of monocytes and macrophages in the body and plays an important role in the innate immunity to certain infections, including M. tuberculosis. In a meta-analysis, it was shown that a low level of vitamin D correlates with a high risk of tuberculosis. The work revealed statistically significant differences in the frequency of alleles and genotypes of the ApaI polymorphism (rs7975232) with the incidence of tuberculosis in ethnic Kazakhs. The presence of the ApaI allele has been shown to significantly reduce the risk of developing tuberculosis.

Keywords:

A gene vitamin D receptor, polymorphism FokI, TaqI, BsmI, ApaI and Cdx2, VDR, pulmonary tuberculosis.

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