ETIOLOGICAL AND DIAGNOSTIC IMMUNOHISTOCHEMICAL INDICES OF PLEOMORPHIC ADENOMAS OF SALIVARY GLANDS
Abstract
Resume. The purpose of the research was to determine etiological and diagnostic immunohistochemical indices of pleomorphic adenomas of the salivary glands. The immunohistochemical study was conducted based on excisional biopsies of pleomorphic adenomas of the salivary glands in 20 patients. The analyses of the research showed that the parotid salivary gland was aƦected in most of the patients with pleomorphic adenomas. Among the viruses that were present – 16 (80%) patients had human papillomavirus type 16 (HPV type 16), and 6 (30%) patients had the Epstein–Barr virus (EBV) dominating. Among the hormones, the distribution was as follows: oestrogen and progesterone in 2 (10%) cases, respectively. PLAG1 had the highest expression in the parotid salivary gland tissues – 18 (90%) cases. The analyses of the
immunohistochemical research of the etiological and diagnostic indices of pleomorphic
adenomas of the salivary glands showed the expression of 5 markers – HPV type 16, EBV, estrogen, progesterone, Plag 1.
Keywords:
salivary gland tumours, pleomorphic adenoma, immunohistochemistry, oestrogen, progesterone, human papillomavirus type 16, Epstein-Barr virus, PLAG1References
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