ETIOLOGICAL FACTORS AND PATHOGENETIC MECHANISMS OF THE WOUND PROCESS: A MODERN VIEW (LITERATURE REVIEW)
DOI:
https://doi.org/10.54890/1694-8882-2025-3-72Abstract
The article provides a comprehensive and in-depth analysis of the literature of foreign authors devoted to the main aspects of the diagnosis, monitoring and screening of the course of the wound process. The findings support the multifactorial and multi-step nature of the wound-healing process, revealing the role of interacting immune, microbiological, and biochemical mechanisms. Pathogenetics is a prominent part of modern comprehensive wound care. These include ointments, pharmaceuticals with antiseptic and antibacterial properties, as well as biopolymer-based adhesives and wound healing materials. Current research focuses not only on improving the effectiveness of local therapy, but also on optimizing methods for systemic modification of inflammatory responses, prevention of secondary complications, and improvement of repair processes. The analysis emphasizes the role of innovative technologies in wound treatment, including the development of new drug forms with long-lasting effects, selective antimicrobial activity and minimal side effects.
Keywords:
wound, pus, wound healing, complicationsReferences
1. Иманкулова А.С., Кожомкулова К.А., Кабаев Б.А., Эмилбеков Ф.М., Толбашиева Г.У., Кудайбердиев А.А. и др. Современные подходы улучшения практики применения антимикробных препаратов в хирургии . Вестник КГМА им. И.К. Ахунбаева. 2021;5-6:43-50.
2. Wilkinson HN, Hardman MJ. Wound healing: cellular mechanisms and pathological outcomes. Open Biol. 2020;10(9):200223. https://doi.org/10.1098/rsob.200223
3. Schreml S, Szeimies RM, Prantl L, Karrer S, Landthaler M, Babilas P. Oxygen in acute and chronic wound healing. Br J Dermatol. 2010;163(2):257-68. https://doi.org/10.1111/j.1365-2133.2010.09804.x
4. Haalboom M. Chronic Wounds: Innovations in Diagnostics and Therapeutics. Curr Med Chem. 2018;25(41):5772-5781. https://doi.org/10.2174/ 0929867324666170710120556
5. Póvoa VCO, Dos Santos GJVP, Picheth GF, Jara CP, da Silva LCE, de Araújo EP, et al. Wound healing action of nitric oxide-releasing self-expandable collagen sponge. J Tissue Eng Regen Med. 2020;14(6):807-818. https://doi.org/10.1002/term.3046
6. Mori R, Tanaka K, Shimokawa I. Identification and functional analysis of inflammation-related miRNAs in skin wound repair. Dev Growth Differ. 2018;60(6):306-315. https://doi.org/10.1111/dgd.12542
7. Eggleston RB. Wound Management: Wounds with Special Challenges. Vet Clin North Am Equine Pract. 2018;34(3):511-538. https://doi.org/10.1016/ j.cveq.2018.07.003
8. Scalise A, Calamita R, Tartaglione C, Pierangeli M, Bolletta E, Gioacchini M, et al. Improving wound healing and preventing surgical site complications of closed surgical incisions: a possible role of Incisional Negative Pressure Wound Therapy. A systematic review of the literature. Int Wound J. 2016;13(6):1260-1281. https://doi.org/10.1111/iwj.12492
9. Liebers R, Jäger D. Surgical wound immunotherapy. Nat Nanotechnol. 2019;14(1):7-8. https://doi.org/10.1038/s41565-018-0328-3
10. Jiang N, Rao F, Xiao J, Yang J, Wang W, Li Z, et al. Evaluation of different surgical dressings in reducing postoperative surgical site infection of a closed wound: A network meta-analysis. Int J Surg. 2020;82:24-29. https://doi.org/10.1016/ j.ijsu.2020.07.066
11. Ousey K, Rippon MG, Rogers AA, Totty JP. Considerations for an ideal post-surgical wound dressing aligned with antimicrobial stewardship objectives: a scoping review. J Wound Care. 2023;32(6):334-347. https://doi.org/10.12968/ jowc.2023.32.6.334
12. Younis I. Dehisced surgical wound. J Wound Care. 2020;29(Sup10a):S18-S19. https://doi.org/10.12968/jowc.2020.29. Sup10a.S18
13. Sandy-Hodgetts K. Surgical wound complications: a 21st century problem? J Wound Care. 2019;28(10):645. https://doi.org/10.12968/jowc.2019.28.10.645
14. Arundel C, Mandefield L, Fairhurst C, Baird K, Gkekas A, Saramago P, et al. Negative pressure wound therapy versus usual care in patients with surgical wound healing by secondary intention in the UK (SWHSI-2): an open-label, multicentre, parallel-group, randomised controlled trial. Lancet. 2025;405(10490):1689-1699. https://doi.org/10.1016/S0140-6736(25) 00143-6
15. Liosatos K, Tobiano G, Gillespie BM. Patient participation in surgical wound care in acute care settings: An integrative review. Int J Nurs Stud. 2024;157:104839. https://doi.org/10.1016/j.ijnurstu.2024.104839
16. Bolton L. Platelet-Rich Plasma: Optimal Use in Surgical Wounds. Wounds. 2021;33(8):219-221.
17. Hwekwete A. Best practices for surgical wound management. Br J Nurs. 2025;34(12):S4-S10. https://doi.org/10. 12968/bjon.2024.0401
18. Young S. Wound assessment. Br J Community Nurs. 2019;24(Sup9):S5. https://doi.org/10.12968/bjcn.2019.24.Sup9.S5
19. Cortesi R, Sguizzato M, Ferrara F. Lipid-based nanosystems for wound healing. Expert Opin Drug Deliv. 2024;21(8):1191-1211. https://doi.org/10.1080/ 17425247.2024.2391473
20. Li S, Renick P, Senkowsky J, Nair A, Tang L. Diagnostics for Wound Infections. Adv Wound Care (New Rochelle). 2021;10(6):317-327. https://doi.org/10.1089/ wound.2019.1103
21. Quain AM, Khardori NM. Nutrition in Wound Care Management: A Comprehensive Overview. Wounds. 2015;27(12):327-335. PMID: 27447105.
22. Molan P, Rhodes T. Honey: A Biologic Wound Dressing. Wounds. 2015;27(6):141-51. PMID: 26061489.
23. De Francesco F, Ogawa R. From Time to Timer in Wound Healing Through the Regeneration. Adv Exp Med Biol. 2024;1470:1-18. https://doi.org/10.1007/ 5584_2024_815
24. Harding K. Innovation and wound healing. J Wound Care. 2015;24(4 Suppl):7-13.https://doi.org/10.12968/jowc. 2015.24.Sup4b.7
25. Tomic-Canic M, Wong LL, Smola H. The epithelialisation phase in wound healing: options to enhance wound closure. J Wound Care. 2018;27(10):646-658. https://doi.org/10.12968/jowc.2018.27.10.646
26. Zielins ER, Brett EA, Luan A, Hu MS, Walmsley GG, Paik K, et al. Emerging drugs for the treatment of wound healing. Expert Opin Emerg Drugs. 2015;20(2):235-46. https://doi.org/10.1517/14728214.2015.1018176
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