ETIOSTRUCTURE AND ANTIBIOTIC RESISTANCE OF PNEUMOTROPIC PATHOGENS IN VENTILATOR-ASSOCIATED PNEUMONIA IN CHILDREN OF THE FIRST TWO MONTHS
DOI:
https://doi.org/10.54890/.v1i1.232Abstract
Resume. The etiostructure of ventilator-associated pneumonia (VAP) and antibiotic resistance of pneumotropic pathogens in sick children of the first two months of life were
studied.
Materials and methods of research. The object of the study was 98 children with VAP. The
collection of biomaterial from the endotracheal tube was carried out by a protected technique
developed by us through a vacuum aspirator, eliminating the risk of contamination. The
following nutrient media were used in the microbiological study: 5% blood agar, chocolate
agar, yolk-salt agar, Saburo medium, Endo medium. Results: in the etiostructure of ventilator-
associated pneumonia, gram-negative flora prevails (53.42% vs. 31.96%, p<0.05) in almost
equal proportions in both full-term and premature infants (p>0.05). The high resistance of the
pneumopathogenic gram-positive microflora to all antibiotics widely used in neonatology was
revealed: penicillins, cephalosporins of the 2nd and 3rd generation, macrolides of the 1st
generation. Gram-negative pneumophilogenic microflora is resistant to almost all antibiotics
used in neonatology practice.
Keywords:
Ventilator-associated pneumonia, antibiotic sensitivity, antibiotic resistance, gram-positive microflora, gram-negative microflora, newborn babies, premature, full-term, intensive care unit, children under two months.References
1. Latania K L, Robert A W. The Epidemiology of Carbapenem-Resistant Enterobacteriaceae: The Impact and Evolution of a Global Menace. Оfficial journal of the Infectious Diseases. Letters. 2017;15(1):28-36. http://doi.org/10.1093/infdis / jiw282.
2. Kathleen C, Molly H, Jeffrey S G, Pranita D T. Treatment of Carbapenem-Resistant Enterobacteriaceae Infections in Children. Journal of the Pediatric Infectious Diseases Society. Letters. 2020;9(1):56-66. http://doi.org/10.1093 / jpids /piz085.
3. Aimee M D, David P N, Jennifer E G. Management of Pneumonia in the Pediatric Critical Care Unit. An Area for Antimicrobial Stewardship. Current Pediatric Reviews. Letters. 2017;13(1):49-66. http://doi.org/10.2174/1573396312666161205102221.
4. Mark L M, Andre C K. Management of Ventilator-Associated Pneumonia: Guidelines. Clinics in Chest Medicine. Letters. 2018;39(4):797-808 http://doi.org/10.1016/j.ccm.2018.08.002
5. Izeta S, Husref T, Vincenzo Di C, Cinzia A. Bacterial sepsis in neonates: Single centre study in a Neonatal intensive care unit in Bosnia and Herzegovina. Acta Medica Academica. Letters. 2017;46(1):7-15. http://doi.org/10.5644/ama2006-124.181.
6. Shrey M, Aline F, Julia B, Johannes Van D, Mike S. Antibiotic use for community-acquired pneumonia in neonates and children: WHO evidence review. Paediatrics and International Child Health. Letters. 2018;38(1):66-75. http://doi.org/10.1080/20469047.2017.1409455.
7. Sujata B, Sangita S, Shyam K M, Hari P K, Keshab P, Jeevan B S. Biofilm Formation by Pathogens Causing Ventilator-Associated Pneumonia at Intensive Care Units in a Tertiary Care Hospital: An Armor for Refuge. BioMed Research International. Letters. 2021. http://doi.org/10.1155/2021/8817700
8. Chand W, Neeraj G. Pediatric Blood Cultures and Antibiotic Resistance: An Overview. Indian Journal of Pediatrics. Letters. 2020;87(2):125-131. http://doi.org/10.1007 / s12098-019-03123-у
Downloads
Published
How to Cite
Issue
Section
