STRUCTURAL CHANGES IN CEREBRUM NEURONS AFTER EXPERIMENTAL AND CLINICAL TRAUMATIC HEAD INJURY
Abstract
Structural changes in cerebrum' neurons after experimental and clinical traumatic head injury were studied at white mongrel rats. In the results of investigation pericyteal edema, neurons' necrosis with swelling, cell's lysis and intracellular content release were observed. There were vessels emptying,
slumpt capillaries, perivascular edema in peripheral areas of lesion territory. In the presence of brain cortex undamaged state among neurons majority the apoptosis occurred as chromatin condensation, cytoplasm shrinkage.
Keywords:
TBI, apoptosis, hypoxiaReferences
1. Rink A., Fung К , Trojanowski J. — Evidence of apoptotic cell death after experimental traumatic brain injury in the rat. - Amer. J. Pathology, 1995, 147, 6: 1575-1584.
2. Adams JH, Doyle D, Graham Dl, Lawrence AE, McLellan DR, Gennarelli ТА, Pastuszko M, Saka moto T (1985) The contusion index: A reappraisal in human and experimental non-missile injury. Neuropathol Appl Neurobiol 11:299-308.
3. Cervos-Navarro J, Lafiiente JV (1991) Traumatic brain injuries: structural changes. J Neural Sc/103:s3-sl4.
4. Kotarka MJ, Graham DJ, Aams JH, Gennarelli ТА (1992) Hippocampal pathology in fatal nonmissile human hea injury. Acta Neuropattol 83:530-534.
5. Ross DT, Graham DI, Adams JH (1993) Selective loss of neurons from the thalamic reticular nucleus following severe human head injury. JNeurotrauma 10:151-165
