TREATMENT OF CHRONIC FOCI OF INFECTION OF UPPER RESPIRATORY TRACT AND THE RESPIRATORY TRACT
Abstract
Studied the effectiveness of Ribomunil in 1018 patients with recurrent otitis media, sinusitis, rhinopharyngitis,rhinosinusitis аnd pharyngolaryngitis. Ribomunyl reduced the frequency of episodes of infectious diseases in patients, the incidence of sinusitis, rhinopharyngiti , rhinosinusitis, farinotonzilitov decreased by 90% , infectious rhinitis 40% , acute otitis media by 25% , reducing the umber of bronchopulmonary complications by 75 %. Were the results regarding the duration of episodes of illness, antibiotic use ( reduced demand by 71% ), use of adjuvant therapy ( 57% reduction ).
References
1. Brantzaeg P. Overview of the mucosal immune system. Current Topics in Microbiology 1990; 140: 13.
2. Bessler WG, Sadelmeir E. Biological activity of bacterial cell wall components: Immunogenicity of an immunostimulating bacterial extract. Arzneimittel-Forschung (Drug Research) 1993; 43: 502-507.
3. Czerkinsky C, Russel MW, Lycke N et al. Oral Administration of streptococcal antigen coupled to cholera toxin B subunit evokes strong antibody responses in salivary glands and extramucosal tisues. Infection and Immunity 1989; 57: 1072.
4. Galioto GB, Mevio E, Maserati R. Bacterial adherence and upper respiratory tract disease: a correlation between S. pyogenes attachment and recurrent throat infections. Acta Otorhynolaryngologica 1988; 454 (Suppl.): 167-174.
5. McGhee JR, Mestecky J, Dertzbaugh MT et al. The mucosal immune system. From fundamental concepts to vaccine development. Vaccine 1992; 10: 75-88.
6. Mestecky J, mcGhee JR. Immunoglobulin A (IgA):molecular and cellular ineractions involved in IgA biosynthesis and immune response. Advances in Immunology 1987; 40: 153.
7. Mestecky J. The common mucosal immune system and current strategies for induction of immune responses in external secretions. Journal of Clinical Immunology 1987; 7: 265.
8. Nega J, McGhee JR, Kiyono H. Cytokine and Ig-producing cellsin mucosal еffector tissues: analysis of IL-5 and IFN-g producing cells, T cells, T cell receptor expression and IgA plasma cells from mouse salivary gland-associated tissues. Journal of Immunology 1992; 148: 2030-2039.
9. Roques C., Frayret M.N., Luc J., et al.Immunostimulant effect on granulocyte functions during an acute respiratory infection. Dev. Biol. Stand., 77, 183, 1992.
10. Хорошилова Н.В. Клинико-иммунологическая оценка эффективности применения рибомунила и низкоинтенсивной лазерной терапии у пациентов с хроническим бронхитом: Автореферат дис .канд.мед.наук. – М., 1994.
