THE SYNTHESIS AND STUDY OF BIOLOGICAL ACTIVITY OF 2,4-SUBSTITUTED QUINAZOLINES
Abstract
The number of syntheses of 2,4-substituted quinazolines was performed and its biological activity was investigated. Results of researches demonsrtaed that investigated 2-H (methylthio) quinazoline-4-ilydeneacetic ethers have grows regulating and fungicide activity.
Keywords:
2,4-substituted quinazolines, synthesis, biological activity, fungicideReferences
1. Chaurasia M. R., Sharma S. K., Kumar R. Synthesis of new 6,8-disubstituted 2-guanidino-4(3H)-quinazolinones as potential antifungal agents// Agric. Biol. Chem. 1990.- Vol. 44. N 3. P. 663-665.
2. Noolvi M.N., Patel H.M., Bhardvaj V., Chauhan A. Synthesis and in vitro antitumor activity of substituted quinazoline and quinoxaline derivatives: Search of anticancer agent. European Journal of Medical Chemistry 2011; 46: 2327-2346.
3. Patel N.B., Patel J.C. Synthesis and antimicrobial activity of Schiff bases and 2-azetidinones derived from quinazolin-4-(3H)-one. Arabian Journal of Chemistry. 2011; 4. 403-411.
4. Загуляева О.А., Мамаев В.П. Пиримидины. X. Взаимодействие замещенных 2-хлорпиримидинов с Na-производными малонового и циануксусного эфиров и динитрила малоновой кислоты // Химия гетероцикл. соедин. - Рига, 1997. - Сб. 1. Азотсодержащие гетероциклы. - С. 354-459.
5. Tulyahseva, B.F. Rasulev, K.K. Turgunov, A.G. Tojiev, B. Tashkhodjaev, N.D. Abdullaev, Kh.M. Shakhidoyatov, Synthesis, Tautomeric States and Crystal Structure of (Z)-Ethyl 2-Cyano-2-(3H-Quinazoline-4-ylidene) Acetate and (Z)-Ethyl 2-Cyano-2-(2-Methyl-3H-Quinazoline-4-ylidene) Acetate. Molecules. 2005. 10. P.1209-1221.
