CORRECTION OF THE SYSTEMIC INFLAMMATORY REACTION SYNDROME IN PATIENTS WITH CHOLECYSTITIS COMPLICATED WITH LOCAL PERITONITIS

Abstract

Summary. The aim is to evaluate the results of correction of the systemic inflammatory response syndrome (SIRS) in patients with cholecystitis complicated by localized peritonitis. The paper presents the results of 46 patients who underwent emergency surgery in the period from 2018 to 2020 inclusive, with the indicators of the systemic inflammatory response syndrome were determined: clinical (temperature, respiratory rate, pulse rate) and laboratory (leukocytes, leukocytal intoxication index). In order to correct SIRS, perioperative antibiotic administration, regional lymph stimulation into the round ligament of liver, irrigation of the abdominal cavity and the wound with ozonized sodium chloride solution with an ozoneconcentration of 8-10 μg/ml and intravenous administration of an ozonized solution with an ozone concentration of 3-4 μg/ml were used. For the correction of immunologic reactivity, thymalin was used, 10 mg intramuscularly, for a treatment course of 3-4 injections. Infusion therapy included hepatotropic drugs. Analysis of the dynamics of the systemic inflammatory response syndrome showed that when we use correction measures with an increase in the period after surgery, there is a decrease in the syndrome tests. No progression of the inflammatory process was observed. The obtained results confirmed the feasibility of using correction methods.