EXPERIMENTAL ESTIMATION OF THE INFLUENCE OF CANAMYCIN, CEFTRIAXONE, CYPROFLOXACIN AND GENTAMICIN ON THE FORMATION OF THE ADHESION PROCESS IN THE ABDOMINAL CAVITY

Abstract

Summary. The process of adhesion formation is a polyetiological phenomenon with a complex pathogenesis. Adhesion and antiadhesive properties of the peritoneum are interrelated, and the predominance of one over the other is likely to have a fundamental effect on the severity of adhesions. It has been proven that the adhesion process is the result of a disruption of the normal course of inflammatory and reparative processes, as evidenced by local resistance factors (phagocytic activity of neutrophils, macrophages, cytokines, and others). The basis of the pathogenesis of the adhesive process is the organization of the tissues of the fibrin matrix formed after intraperitoneal exudation of free fibrin, the active phase of which begins as early as 12 hours after injury of the peritoneum. The basis of the pathogenesis of adhesions after operations on the abdominal organs is considered to be the germination of connective tissue fibers and, subsequently, vessels and nerves that have fallen out of the peritoneal effusion of fibrin, which "joins" the serous cover of the organs. In the course of the study, we conducted a randomized controlled study to experimentally evaluate the effect of antibacterial agents on the formation of adhesions in the abdominal cavity. In a parallel randomized study, the results of the effect of various antibacterial agents on the formation of adhesions in the abdominal cavity are presented. An experimental study was carried out on 80 outbred rats. The antibiotics Kanamycin, Ceftriaxone, Gentamycin, Ciprofloxacin were used in four experimental groups.