ЭКСПЕРИМЕНТАЛЬНАЯ ОЦЕНКА ВЛИЯНИЯ ВАНКОМИЦИНА,  ЛЕВОФЛОКСАЦИНА И МЕТРОНИДАЗОЛА НА ПРОЦЕСС  ФОРМИРОВАНИЯ СПАЕЧНОГО ПРОЦЕССА В БРЮШНОЙ ПОЛОСТИ

А.А.  Sopuev; E.E.  Kudaiarov; М.К.   Ormonov; А.К.  Kadyrov; A.B.  Baurov; A.J.  Djainakov

doi:10.54890/.v1i1.65

А.А. Sopuev E.E. Kudaiarov М.К. Ormonov А.К. Kadyrov A.B. Baurov A.J. Djainakov

DOI:

https://doi.org/10.54890/.v1i1.65

Abstract

Summary. The process of adhesion formation is a polyetiological phenomenon with a
complex pathogenesis. Adhesion and antiadhesive properties of the peritoneum are
interrelated, and the predominance of one over the other is likely to have a fundamental
effect on the severity of adhesions.
The basis of the pathogenesis of adhesions after operations on the abdominal organs is
considered to be the germination of connective tissue fibers and, subsequently, vessels and
nerves that have fallen out of the peritoneal effusion of fibrin, which "joins" the serous
cover of the organs.
The basis of the pathogenesis of the adhesive process is the organization of the tissues of the fibrin matrix formed after intraperitoneal exudation of free fibrin, the active phase of which
begins as early as 12 hours after injury of the peritoneum.
In the course of the study, we conducted a randomized controlled study to experimentally
evaluate the effect of antibacterial agents on the formation of adhesions in the abdominal
cavity. In parallel randomized study presents the results of the impact of antibiotiсs on the
adhesion formation of the abdominal cavity. An experimental surgery was conducted on 60
outbred rats. In three experimental groups were used: Vancomycin, Levofloxacin and
Metronidazole.

Keywords:

Vancomycin, Levofloxacin, Metronidazole, adhesive disease of the abdominal cavity, sanitation of the abdominal cavity, adhesion process.

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