ОЦЕНКА ЭФФЕКТИВНОСТИ ЛЕЧЕНИЯ ГИПЕРЕСТЕЗИИ ЗУБОВ С  ИСПОЛЬЗОВАНИЕМ ДЕСЕНСИБИЛИЗИРУЮЩИХ АГЕНТОВ ЗУБНЫХ ПАСТ.  СИСТЕМАТИЧЕСКИЙ ОБЗОР

N.G. Sarkisyan; E.F. Gaisina; P.I.  Astryukhina

doi:10.54890/.v2i2.317

N.G. Sarkisyan E.F. Gaisina P.I. Astryukhina

DOI:

https://doi.org/10.54890/.v2i2.317

Abstract

Annotation. Nowadays dentin hypersensitivity is an urgent problem for patients of various age
groups. The market of individual oral hygiene products provides us a wide choice of toothpastes that
can reduce a teeth sensivity to mechanical and temperature influences. The question of the
effectiveness of the use of various desensitizing toothpastes is still debatable, due to the fact that the
mechanism of desensitizing toothpaste action directly depends on its composition, the size and shape
of the particles of the desensitizing components and its acid resistance in the oral cavity. We
conducted a systematic review, which includes modern randomized controlled and cohort studies, in
order to find the most effective desensitizing components of toothpastes.

Keywords:

dentin hypersensivity, sensitive teeth, obturation of dentinal tubules, desensitizing toothpastes.

References

1. Tavares JA, Lima FA, Ferraz ST, Augustoc CM.The effectiveness of propolis extract in reducing dentin hypersensitivity: A systematic

review. Archives of Oral Biology. 2021;131:105248. DOI:10.1016/j.archoralbio.2021.105248.

2. Alves de Freitas SA, Alves de Oliveira NM, Larocca de Geus J, Souza SFC, Pereira AFV, Bauer J. Bioactive toothpastes in dentin

hypersensitivity treatment: A systematic review. The Saudi Dental Journal. 2021; 33(7):395-403. DOI: 10.1016/j.sdentj.2021.04.004.

3. Toledano-Osorio M, Osorio R, Osorio E, Medina-Castillo AL, Toledano M. Novel pastes containing polymeric nanoparticles for dentin

hypersensitivity treatment: an in vitro study. Nanomaterials. 2021; 11(11):3150. DOI: 10.3390/nano11113150 .

4.Aminoshariae A, Kulild JC. Current Concepts of Dentinal Hypersensitivity. Journal of Endodontics. 2021 Nov;47(11):1696-1702. DOI: 10.1016/j.joen.2021.07.011.

5. Abuzinadah SH, Alhaddad AJ. A randomized clinical trial of dentin hypersensitivity reduction over one month after a single topical

application of comparable materials. Scientific reports. 2021; 11(1):6793. DOI: 10.1038/s41598-021-86258-3.

6. Demirci M, Karabay F, Berkman M, Özcan İ, Tuncer S, Tekçe N, Baydemir C. The prevalence, clinical features, and related factors of dentin hypersensitivity in the Turkish population. Clinical Oral Investigations. 2022; 26(3):2719-2732. DOI: 10.1007/s00784-021-04245-4.

7. Sobral APT, Santos EM, Aranha AC, Soares PV, Moriyama CM, Gonçalves MLL, Ribeiro RA, Motta LJ, Horliana ACRT, Fernandes KPS, Mesquita-Ferrari RA, Bussadori SK. The control of pain due to dentin hypersensitivity in individuals with molar-incisor hypomineralisation: a protocol for a randomised controlled clinical trial. BMJ Open. 2021; 11(3):e044653. DOI: 10.1136/bmjopen-2020-044653.

8. O'Toole S, Bartlett D. The relationship between dentine hypersensitivity, dietary acid intake and erosive tooth wear. Journal of dentistry. 2017;67: 84-87. DOI: 10.1016/j.jdent.2017.10.002.

9. Monterubbianesi R, Sparabombe S, Tosco V, Profili F, Mascitti M, Hosein A, Putignano A, Orsini G. Can desensitizing toothpastes also have an effect on gingival inflammation? A double-blind, three-treatment crossover clinical trial. International journal of environmental research and public health. 2020;17(23):8927. DOI: 10.3390/ijerph17238927.

10. Longridge NN, Youngson CC. Dental Pain: dentine sensitivity, hypersensitivity and cracked tooth syndrome. Primary Dental Journal. 2019; 8(1):44-51. DOI: 10.1177/205016841900800101.

11. MacDonald K, Boudreau E, Thomas GV, Badrock TC, Davies LG, Lloyd ML, Spradbery PS, Turner-Cahill S, Boyd D. In vitro evaluation of Sensi-IP : A soluble and mineralizing sensitivity solution. Heliyon. 2021;8(1):e08672.DOI: 10.1016/j.heliyon.2021.e08672.

12. Liu X, Tenenbaum HC, Wilder RS, Quock R, Hewlett ER, Ren Y. Pathogenesis, diagnosis and management of dentin hypersensitivity: an

evidence-based overview for dental practitioners. BMC Oral Health. 2020;20(1):220. DOI: 10.1186/s12903-020-01199-z.

13. Еловикова Т.М., Ермишина Е.Ю., Уварова Л.В., Кощеев А.С. Решение проблемы повышенной чувствительности дентина:

механизмы реминерализации при курсовом использовании зубной пасты с фторидом олова. Стоматология. 2019;98(5):66-71. DOI:

17116/stomat20199805166. [Elovikova TM, Ermishina EYU, Uvarova LV, Koshcheev AS. Resheniye problemi povishennoi chuvstvitelnosti

dentina mekhanizmi remineralizatsii pri kursovom ispolzovanii zubnoi pasti s ftoridom olova. Stomatologia (Russian Journal of dentistry).

;98(5):66-71. (In Russ.)] DOI: 10.17116/stomat20199805166.

14. Хамадеева А.М., Комарина Т.А. Планирование лечения гиперестезии зубов. Институт стоматологии. 2006;3 (32): 72-77.

[Khanadeyeva AM, Komarina TA. Planirovaniye lecheniya giperestezii zubov. Institut stomatologiyi.2006; 3 (32): 72-77. (In Russ.)]

15. Kar PP, Shaikh ZA, Hiremath AM, Vikneshan M. Comparison of the effectiveness of three different desensitizing toothpastes in

reducing dentin hypersensitivity: A 4-week clinical study. Clinical Oral Investigations. 2019;22(2):181-184. DOI: 10.4103/JCD.JCD_304_18.

16. Булкина Н.В., Пудовкина Е.А., Акулович А.В., Захаревич А.М. Изменение морфологии поверхности дентина после обработки

поверхности пастами с гидроксиапатитом и с наногидроксиапатитом кальция. Стоматология.2014;93(1):11-15. [Bulkina N.V., Pudovkina E.A., Akulovich A.V., Zaharevich A.M. Izmenenie morfologii poverhnosti dentina posle obrabotki poverhnosti pastami s gidroksiapatitom i s nanogidroksiapatitom kal'ciya. Stomatologiya. 2014; 93(1):11-15. (in Russ.)]

17. Liu H, Hu D. Efficacy of a Commercial Dentifrice Containing 2% Strontium Chloride and 5% Potassium Nitrate for Dentin Hypersensitivity: A 3-Day Clinical Study in Adults in China. Clinical therapeutics. 2012;34(3):614-22. DOI: 10.1016/j.clinthera.2012.01.027.

18. Martins CC, Firmino RT,Riva JJ, Ge L,Carrasco-Labra A, Brignardello-Petersen R, Colunga-Lozano LE, Granville-Garcia AF, Costa FO, Yepes-Nuñez JJ, Zhang Y, Schünemann HJ. Desensitizing Toothpastes for Dentin Hypersensitivity: A Network Meta-analysis. Journal of dental research. 2020; 99(5):514-522. DOI: 10.1177/0022034520903036.

19. Creeth JE, Burnett GR. Efficacy of an experimental occlusion technology toothpaste in the relief of dentinal hypersensitivity: an 8-week

randomised controlled trial. Quintessence publishing Deutschland. 2021; 19(1):195-202. DOI: 10.3290/j.ohpd.b1075109.

20. Pei D, Meng Y, Li Y, Liu J, Lu Y. Influence of nano-hydroxyapatite containing desensitizing toothpastes on the sealing ability of dentinal

tubules and bonding performance of self-etch adhesives. Journal of the mechanical behavior of biomedical materials. 2019; 91: 38-44. DOI:

1016/j.jmbbm.2018.11.021.

21. Shiau HJ. Dentin Hypersensitivity. Journal of evidence based dental practice. 2012;12(3): 220-228. DOI: 10.1016/S1532-3382(12)70043-X.

22. Berg C, Unosson E, Engqvist H, Xia W. Comparative study of technologies for tubule occlusion and treatment of dentin hypersensitivity. Journal of functional biomaterials. 2021; 12(2): 27. DOI: 10.3390/jfb12020027.

23. Еловикова Т.М., Ермишина Е.Ю., Кощеев А.С., Приходкин А.С. Клинико-лабораторное обоснование применения лечебно-профилактической десенситивной зубной пасты с фторидом натрия молодыми пациентами. Проблемы стоматологии.2018;14(2):5-11. DOI: 10.18481/2077-7566-2018-14-2-5-11 [Elovikova TM, Ermishina EYU, Kosheyev AS, Prokhodkin AS. Kliniko-laboratornoye obosnovaniye primeneniya lechebno-proflikticheskoy desensetivnoi zubnoi pasti s ftoridom olova. Problemi stomatologiyi(Russian Journal of dentistry). 2018;14(2):5-11. (In Russ.)] DOI: 10.18481/2077-7566-2018-14-2-5-11.

24. Bhowmik E, Chandrashekhar DP, Hareesha MS. Comparative evaluation of fluorinol and calcium sodium phosphosilicate-

containing toothpastes in the treatment of dentin hypersensitivity. International journal of dental hygiene. 2021;19(4): 421-428. DOI:

1111/idh.12495.

25. Huang X, Li R, Feng Y, Wang Y. Remineralization of demineralized dentin induced by bioactive glass NovaMin. Journal of Central South University. 2018;43(6):619-624. DOI: 10.11817/j.issn.1672-7347.2018.06.007.

26. Acharya A, Surve S, Thakur S. A clinical study of the effect of calcium sodium phosphosilicate on dentin hypersensitivity. Journal of clinical and experimental dentistry. 2013; 5(1): e18-e22. DOI:10.4317/jced.50955.

27. Sriranganathan D, Chen X, Hing KA, Kanwal N, Hill RG. The effect of the incorporation of fluoride into strontium containing bioactive

glasses. Journal of non-crystalline solids. 2017; 457: 25-30. DOI:10.1016/j.jnoncrysol.2016.11.018.

28. Creeth JE, Goyal C, Qaqish J, Maclure R, Holt JS. Efficacy of an occluding toothpaste on dentinal hypersensitivity over 14 days. BDJ Open. 2021; 7(1):26. DOI: 10.1038/s41405-021-00076-3.

29. Burnett GR. The effects of an experimental anhydrous stannous fluoride dentifrice on the acid resistance of dentin smear layers. American journal of dentistry. 2013; 26(Spec No A):15A-18A.

30. Parkinson CR, Hughes N, Hall C, Whelton H, Gallob J, Mason S. Three randomized clinical 2016; 29(1): 25-32.

31. Chaknis P, Panagakos, FS, DeVizioW, Sowinski J, Petrone D, Proskin H. Assessment of hypersensitivity reduction of a dentifrice

containing 0.3% triclosan, 2.0% PVM/MA copolymer, 0.243% NaF and specially-designed silica as compared to a dentifrice containing 0.454% stannous fluoride, sodium hexametaphosphate and zinc lactate and to a dentifrice containing 0.243% NaF on dentin hypersensitivity reduction: an 8-week study. American journal of dentistry. 2011; 24 (Spec No A):14A-20A.

32. Seong J, Newcombe RG, Foskett HL, Davies M, West XN. A randomised controlled trial to compare the efficacy of an aluminium lactate/potassium nitrate/hydroxylapatite toothpaste with a control toothpaste for the prevention of dentine hypersensitivity. Journal of

dentistry. 2021; 108:103619. DOI: 10.1016/j.jdent.2021.103619.

33. Asmari DA, Khan MK. Evaluate efficacy of desensitizing toothpaste containing zinc-carbonate hydroxyapatite nanocrystals: non-

comparative eight-week clinical study. Journal of international society of preventive & community dentistry. 2019; 9(6):566-570. DOI: 10.4103/jispcd.JISPCD_261_19

34. Tschoppe P, Zandim DL, Martus P, Kielbassa AM. Enamel and dentine remineralization by nano-hydroxyapatite toothpastes. Journal of dentistry. 2011; 39(6): 430-7. DOI: 10.1016/j.jdent.2011.03.008.

35. Rimondini L, Palazzo B, Iafisco M,Canegallo L, Demarosi F, Merlo M, Roveri N. The remineralizing effect of carbonate-hydroxyapatite nanocrystals on dentine. Materials Science Forum. 2007; 539-543: 602-605. DOI:10.4028/www.scientific.net/MSF.539-543.602.

36. Orsini G, Procaccini M, Manzoli L, Giuliodori F, Lorenzini A, Putignano A. A double-blind randomized-controlled trial comparing the

desensitizing efficacy of a new dentifrice containing carbonate/hydroxyapatite nanocrystals and a sodium fluoride/potassium nitrate dentifrice. Journal of clinical periodontology. 2010;37(6):510-517. DOI: 10.1111/j.1600-051X.2010.01558.x.

37. Singh A, Shetty B, Mahesh CM, Reddy VP, Chandrashekar BS, Mahendra S. Evaluation of efficiency of two nanohydroxyapatite

remineralizing agents with a hydroxyapatite and a conventional dentifrice:a comparative in vitro study. Journal of Indian orthodontic society. 2017; 51(2): 92-102. DOI:10.4103/jios.jios_13_16.

38. Gul H, Ghaffar MA, Kaleem M, Khan AS. Hydroxyapatite, a potent agent to reduce dentin hypersensitivity. Journal of the Pakistan medical Assotiation. 2021;71(11): 2604-2610. DOI: 10.47391/JPMA.01175.

39. Amaechi BT, Lemke KC, Saha S, Luong MN, Gelfond J.Clinical efficacy of nanohydroxyapatite-containing toothpaste at relieving dentin hypersensitivity: an 8 weeks randomized control trial. BDJ Open.2021; 7(1):23. DOI: 10.1038/s41405-021-00080-7.

40. Kim SY, Kim EJ, Kim DS, Lee IB. The evaluation of dentinal tubule occlusion by desensitizing agents: a real-time measurement of

dentinal fluid flow rate and scanning electron microscopy. Operative dentistry. 2013; 38(4):419-428.DOI: 10.2341/11-504-L.

41. Bonetti AG, Pazzi E, Zanarini M, Marchionni S, Checchi L. The effect of zinc-carbonate hydroxyapatite versus fluoride on enamel surfaces after interproximal reduction. Wiley periodicals. 2014;36(3):356-361. DOI: 10.1002/sca.21125.

42. Satyapal T, Mali R, Mali A, Patil V.Comparative evaluation of a dentifrice containing calcium sodium phosphosilicate to a dentifrice containing potassium nitrate for dentinal hypersensitivity: A clinical study. Journal of indian society of periodontology. 2014;18(5):581-5. DOI:

4103/0972-124X.142447.

43. Веkes E, Heinzelmann K.Efficacy of desensitizing products containing 8% arginine and calcium carbonate for hypersensitivity relief in MIH-affected molars: an 8-week clinical study.Clinical oral investigations.2017; 21(7): 2311–2317. DOI: 10.1007/s00784-016-2024-8.

44. Vu Pham TA, Anh Nguyen TT. Clinical evaluation of the desensitizing efficacy of a paste containing 8% arginine and calcium carbonate.

Journal of dental problem and solutions.2016; 3(3): 050-054. DOI: 10.17352/2394-8418.000035.

45. Arantes D, Limeira F, Yamauti M, Moreira A, Abreu L, Agalhaes C. Comparison of Clinical Efficacy of Pro-Argin and NovaMin

Toothpastes in Relieving Dentin Hypersensitivity: A Systematic Review and Meta-analysis. trials to assess the short-term efficacy of anhydrous 0.454% w/w stannous fluoride dentifrices for the relief of dentin hypersensitivity. American journal of dentistry. Quintessence publishing Deutschland. 2019;17(5):403-412. DOI:10.3290/j.ohpd.a43272.

46. Arshad S, Zaidi S, Farooqui W. Comparative efficacy of BioMin-F, Colgate Sensitive Pro-relief and Sensodyne Rapid Action in relieving dentin hypersensitivity: a randomized controlled trial. BMC Oral Health. 2021;21 (1):498. DOI: 10.1186/s12903-021-01864-x

47. Schiff T, Delgado E, Zhang YP, Cummins D, DeVizio W, Mateo LR. Clinical evaluation of the efficacy of an in-office desensitizing paste

containing 8% arginine and calcium carbonate in providing instant and lasting relief of dentin hypersensitivity. American journal ofdentistry.

; Spec. No. 8A-15A.

48. Yan B, Yi J, Li Y, Chen Y, Shi Z. Arginine-containing toothpastes for dentin hypersensitivity: systematic review and meta-analysis. Quintessence publishing Deutschland. 2013; 44(9):709-723. DOI: 10.3290/j.qi.a30177.

49. Magno MB, Nascimento GC, Da Penha NK, Pessoa OF, Loretto SC, Maia LC. Difference in effectiveness between strontium acetate and

arginine-based toothpastes to relieve dentin hypersensitivity: a systematic review. American Journal of dentistry. 2015; 28(1):40-4.

50. Vinaya KR, Shubhashini N, Seshan H, Kranti K. A clinical trial comparing a stannous fluoride based dentifrice and a strontium chloride

based dentifrice in alleviating dentinal hypersensitivity. Journal of International Oral Health. 2010; 2(1), 37-50.

51. Hu M, Zheng G, Lin H, Yang M, Zhang Y, Han J. Network meta-analysis on the effect of desensitizing toothpastes on dentine hypersensitivity. Journal of dentistry. 2019;88:103170. DOI: 10.1016/j.jdent.2019.07.008.

52. West XN, Seong J, Davies M. Management of dentine hypersensitivity: efficacy of professionally and self-administered agents. Journal of clinical periodontology. 2014;42:256-302. DOI: 10.1111/jcpe.12336.