CHANGES IN THE QUALITATIVE AND QUANTITATIVE PARAMETERS OF THE SALIVARY GLANDS IN PATIENTS WITH END-STAGE CHRONIC RENAL FAILURE BEFORE AND AFTER KIDNEY TRANSPLANTATION

Abstract

Summary. The authors conducted a study of the state of the salivary glands in 50 patients with end-
stage chronic renal failure. A pronounced violation of the function of the salivary glands (SG) in these
patients by the type of xerostomia was established, which led to a change in the qualitative and
quantitative indicators of mixed saliva. After kidney transplantation, SG function improves, but is not
fully restored. An improvement in the hygienic condition of the oral cavity is also noted.
The secret of SG cleanses the oral mucosa from bacteria and food. Saliva immunoglobulins and
lysozyme are involved in the formation of oral immunity. Saliva forms a food bolus and makes it
easier to swallow food. Reduced salivation leads to indigestion and caries. All patients with end-stage
chronic renal failure had damage to all SG. A decrease in kidney function led to a change in the
composition and nature of salivation. In patients with saliva, toxic products were excreted, which are
normally excreted only by the kidneys. Normalization of salivation occurred after hemodialysis.
Patients after kidney transplantation require dispensary observation and preventive therapy of the salivary glands in order to improve and restore their function. Currently, there is no information in
the literature on the state of SG in patients after kidney transplantation. This was the basis for the
present work.