THE GENDER-SPECIFIC SURVIVAL RATES AMONG PEOPLE LIVING WITH HIV ON ANTIRETROVIRAL THERAPY IN THE KYRGYZ REPUBLIC
DOI:
https://doi.org/10.54890/1694-8882-2024-5-23Abstract
In the Kyrgyz Republic for the entire period as of 12/31/2023, 13 289 people were living with HIV infection. Testing, treatment, and viral load suppression cascades are 70 - 79 - 90. Treatment approaches and low immune status affect the survival rate of PLHIV receiving ART. The purpose of this study is to conduct a survival analysis in HIV-infected patients on ART as well as to evaluate the efficacy of the treatment depending on gender. Data of 13 289 registered cases in the Kyrgyz Republic among patients of 18 years and older on ART was processed. An analysis of viral loads, the level of CD4 and death rates was carried out at different periods of duration of ART. The duration of ART influences survival rates positively, the latter being higher in women. Women achieve virological effectiveness at the start of ART faster than men. Virological and immunological effectiveness among women on ART is higher than among men. Timely initiated ART increases survival rates, especially among women.
Keywords:
antiretroviral therapy, HIV - infectionReferences
1. World Health Organization. HIV/AIDS. WHO. 2024. Available from: https://www.who.int/news-room/fact-sheets/detail/hiv-aids gad_source=1&gclid=CjwKCAiAibeuBhAAEiwAiXBoJMAWlNm9i7hD1gPYVZMJ2qbikNQ394NvKsn2MZg P6fx90vbyX1HwiBoCfJIQAvD_BwE. Published 13 July 2023. Accessed March 10, 2024.
2. AIDS Center Kyrgyzstan. Available from: https://aidscenter.kg/. Published December 1, 2023. Accessed January 10, 2024.
3. World Health Organization. HIV – Estimated antiretroviral therapy coverage among people living with HIV, WHO. Available from: https://www.who.int/ data/gho/indicator-metadata-registry/imr-details/4477. Accessed March 20, 2024.
4. Lorestani RC, Kazemisafa N, Rostamian M, Akya A, Rezaeian S, Bashiri H, et al. Survival-related factors in HIV/AIDS patients: A retrospective cohort study from 2011 to 2019 in Kermanshah, Iran. Curr HIV Res. Published online June 17, 2022. https://doi.org/10.2174/1570162X20666220617141619
5. Tchounga BK, Hønge BL, Eholie SP, Coffie PA, Jespersen S, Wejse C, et al. Effect of sex and age on outcomes among HIV-2-infected patients starting antiretroviral therapy in West Africa. AIDS. 2016;30(17):2707-2714. https://doi.org/10.1097/ QAD.0000000000001232
6. Akiso M, Muema D, Langat R, Naidoo KK, Oino G, Mutua G, et al. Early antiretroviral therapy and its impact on natural killer cell dynamics in HIV-1 infected men who have sex with men: a cross-sectional pilot study evaluating the impact of early ART initiation on NK cell perturbation in HIV infection. Microbiol Spectr. 2024;12(4):e0357023. https://doi.org/10.1128/ spectrum.03570-23
7. Camici M, Gagliardini R, Lanini S, Del Duca G, Mondi A, Ottou S, et al. Rapid ART initiation with bictegravir/ emtricitabine/tenofovir alafenamide in individuals presenting with advanced HIV disease (Rainbow study). Int J Antimicrob Agents. 2024;63(1):107049. https://doi.org/10.1016/j.ijantimicag.2023.107049
8. Omonov IK, Suranchieva GS, Dzhumagulova ASh. Features of HIV infection depending on the duration of infection. In: Zvereva VV, ed. Collection of theses of young scientists within the framework of the international conference dedicated to the 300th anniversary of the Russian Academy of Sciences. Moscow, 2022. Moscow;Publishing house "Pero".2022:27. Available from: https://elibrary.ru/sdoxgk
9. Mody A, Eshun-Wilson I, Sikombe K, Schwartz SR, Beres LK, Simbeza S, et al. Longitudinal engagement trajectories and risk of death among new ART starters in Zambia: A group-based multi-trajectory analysis. PLoS Med. 2019;16(10):e1002959. https://doi.org/10.1371/journal.pmed.1002959
10. Okonji EF, Mukumbang FC, Orth Z, Vickerman-Delport SA, Van Wyk B. Psychosocial support interventions for improved adherence and retention in ART care for young people living with HIV (10-24 years): a scoping review. BMC Public Health. 2020;20(1):1841. Published 2020 Dec 1. https://doi.org/10.1186/s12889-020-09717-y
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