THERAPY OF METABOLIC SYNDROME AND AGE-RELATED HYPOGONADISM OF MEN

Abstract

Complex therapy was performed on patients with androgen deficiency in combination with various manifestations of metabolic syndrome. The group of patients who received the treatment with testosterone tablets represented positive results in the clinical manifestations of metabolic disorders. The main manifestation of the positive dynamics of treatment is the normalization of the level of total and free Testosterone (up to 12.8 nmol / l, up to 256.9 pmol / l) (p>0.05). Also, there was a significant decrease in body weight from 109 kg to 97 kg. Glycolized hemoglobin dropped from 5.6% to 3.6%. Globulin-binding sex hormone levels have normalized to 30.6 nmol/l. There was a statistically significant decrease in cholesterol to 3.8 mmol/l, low-density lipoproteins to 3.6 mmol/l, the atherogenicity index to 3.4. The ICEF and IPSS questionnaire indicators improved. Received data confirm the need to correct androgen deficiency in the treatment of metabolic syndrome in men, since with the normalization of the level of total and free testosterone in the blood, there is a clinically significant normalization of metabolic disorders.