ASSESSMENT OF VITAMIN D PROVISION OF THE POPULATION OF THE KYRGYZ REPUBLIC

Abstract

Relevance. The important role of vitamin D in the functioning of the immune and cardiovascular systems of the body, as well as in various physiological processes, including cell growth and neuromuscular conduction, is known. Its deficiency in the body causes the risk of developing infectious, cardiovascular, cancer and other diseases. In this regard, vitamin D deficiency is an urgent public health problem in the world, including in the Kyrgyz Republic. Target: to study the level of vitamin D provision in different population groups of the Kyrgyz Republic by season. Materials and methods. An analysis of studies of vitamin D content was carried out by the Gemotest laboratory in 6274 people from various regions of the Kyrgyz Republic from January 2019 to August 2023. For laboratory studies, the electrochemiluminescent immunoassay (ECLIA) method is used. Results. The results of vitamin D content (level) by gender, by year, and by region of the Kyrgyz Republic are presented. Conclusions. An analysis of the study showed that in the whole of the Kyrgyz Republic, only 35.48% of those surveyed had an adequate level of vitamin D. The highest proportion of the population with vitamin D deficiency was noted in the southern region of the Kyrgyz Republic (Batken, Jalalabad and Osh regions), mainly more in women and teenagers.

Keywords:

Vitamin D, public health, assessment, deficiency, insufficiency, age groups, seasons, Kyrgyz Republic.

Author Biographies

A.I. Buyuklyanov, International Higher School of Medicine

Department of Public Health

R.M. Atambaeva, Kyrgyz State Medical Academy named after I.K. Akhunbaev

Department of Hygienic disciplines

M.K. Esenamanova, Kyrgyz State Medical Academy named after I.K. Akhunbaev

Department of Hygienic disciplines

F.A. Kochkorova, Kyrgyz State Medical Academy named after I.K. Akhunbaev

Department of Hygienic disciplines

References

1. Мальцев С.В. Современные данные о витамине D - метаболизм, роль в организме, особенности применения в практике врача. Практическая медицина. 2020;18(4):8–22. [Maltsev S.V. Modern data on vitamin D - metabolism, role in the body, features of use in the practice of a doctor. Practical medicine. 2020;18(4):8–22 (in Russ.)]. https://doi.org/10.32000/2072-1757-2020-4-8-22

2. Zhang L, Zhang S, He C, Wang X. VDR Gene Polymorphisms and Allergic Diseases: Evidence from a Meta-analysis. Immunol Invest. 2020;49(1–2):166–177. https://doi.org/10.1080/08820139.2019.1674325

3. Pludowski P, Holick MF, Pilz S, Wagner CL, Hollis BW, Grant WB, et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality review of recent evidence. Autoimmun Rev. 2013;12(10):976-989. https://doi.org/10.1016/j.autrev.2013.02.004

4. Bartley J. Vitamin D, innate immunity and upper respiratory tract infection. J Laryngol Otol. 2010;124(5):465–469. https://doi.org/10.1017/s0022215109992684

5. Zittermann A, Schleithoff SS, Koerfer R. Putting cardiovascular disease and vitamin D insufficiency into perspective. Br J Nutr. 2007; 94(04):483. https://doi.org/10.1079/bjn20051544

6. Ahmed AE, Sakhr HM, Hassan MH, El-Amir MI, Ameen HH. Vitamin D Receptor rs7975232, rs731236 and rs1544410 Single Nucleotide Polymorphisms, and 25-Hydroxyvitamin D Levels in Egyptian Children with Type 1 Diabetes Mellitus: Effect of Vitamin D Co-Therapy. Diabetes Metab Syndr Obes. 2019;12:703–716. https://doi.org/10.2147/DMSO.S201525

7. Sentinelli F, Bertoccini L, Barchetta I, Capoccia D, Incani M, Pani MG, et al. The Vitamin D Receptor (VDR) Gene rs11568820 Variant Is Associated with Type 2 Diabetes and Impaired Insulin Secretion in Italian Adult Subjects, and Associates with Increased Cardio-Metabolic Risk in Children. Nutr Metab Cardiovasc Dis. 2016;26(5):407–413. https://doi.org /10.1016/j.numecd.2016.02.004

8. Shi X.Y., Huang A.P., Xie D.W., Yu X.L. Association of Vitamin D Receptor Gene Variants with Polycystic Ovary Syndrome: A Meta-Analysis. BMC Med Genet. 2019;20(1):32. https://doi.org/10.1186/s12881-019-0763-5

9. Charoenngam N, Shirvani A, Kalajian TA, Song A, Holick MF. The Effect of Various Doses of Oral Vitamin D3 Supplementation on Gut Microbiota in Healthy Adults: A Randomized, Double-blinded, Dose-response Study. Anticancer Res. 2020;40(1):551–556. https://doi.org/10.21873/anticanres.13984

10. Zhang L, Wang S, Che X, Li X. Vitamin D and lung cancer risk: A comprehensive review and meta-analysis. Cell Physiol Biochem 2015; 36 (1):299–305. https://doi.org/10.1159/000374072

11. Группа экспертов высокого уровня. Питание и продовольственные системы. Доклад Группы высокого уровня по продовольственной безопасности и питанию Комитета по всемирной продовольственной безопасности. Рим; 2017. 189 с. Режим доступа: https://www.fao.org/3/I7846RU/i7846ru.pdf

12. Каронова Т.Л., Гринева Е.Н., Никитина И.Л., Цветкова Е.В., Тодиева А.М., Беляева О.Д., и др. Распространенность дефицита витамина D в Северо-Западном регионе РФ среди жителей Санкт-Петербурга и Петрозаводска. Остеопороз и остеопатии. 2013;16(3):3-7. [Karonova T.L., Grinyova E.N., NikitiM I.L., Tsvetkova E.V., Todieva A.M., Belyaeva O.D., Mikheeva E.P., Globa P.Yu., Andreeva A.T., Beletskaya I.S., Omelchuk N.V., Fulonova L.S., Shlyakhto E.V. The prevalence of vitamin D deficiency in the Northwestern region of the Russian Federation among the residents of St. Petersburg and Petrozavodsk. Osteoporosis and Bone Diseases. 2013;16(3):3-7. (In Russ.)]. https://doi.org/10.14341/osteo201333-7

13. Isupova AA, Isupov RV. Determinants of serum 25(OH)D indicators of Kyrgyzstan. Health care of Kyrgyzstan. 2021;4:34-39. https://doi.org/10.51350/zdravkg 2021124334

14. Kondratyeva EI, Loshkova EV, Zakharova IN, Shubina YF, Saprina TV, Nikonova VS, et al. Assessment of vitamin D supply at different age. Meditsinskiy sovet = Medical Council. 2021;(12):294-303. (In Russ.) https://doi.org/10.21518/2079-701X-2021-12-294-303

Published

2024-04-30

Issue

Section

ISSUES OF HYGIENE AND EPIDEMILOGOLIA